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Assessing the Potential of 1,2,3-Triazole-Dihydropyrimidinone Hybrids Against Cholinesterases: In Silico, In Vitro, and In Vivo Studies.

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Title: Assessing the Potential of 1,2,3-Triazole-Dihydropyrimidinone Hybrids Against Cholinesterases: In Silico, In Vitro, and In Vivo Studies.
Authors: Gastalho CM; LAQV-REQUIMTE, Institute for Research and Advanced Training (IIFA), University of Évora, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal.; Institute of Earth Sciences, Institute of Research and Advanced Training, University of Évora, 7000-671 Évora, Portugal.; Academic Clinical Center of Alentejo, C-TRAIL, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal., Sena AM; Department of Chemistry and Biochemistry, School of Sciences and Technologies, University of Évora, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal., López Ó; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, E-41071 Seville, Spain., Fernández-Bolaños JG; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, E-41071 Seville, Spain., García-Sosa AT; Institute of Chemistry, University of Tartu, Ravila 14 A, 50411 Tartu, Estonia., Pereira F; LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal., Antunes CM; Institute of Earth Sciences, Institute of Research and Advanced Training, University of Évora, 7000-671 Évora, Portugal.; Academic Clinical Center of Alentejo, C-TRAIL, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal.; Department of Medical and Health Sciences, School of Health and Human Development, University of Évora, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal., Costa AR; Institute of Earth Sciences, Institute of Research and Advanced Training, University of Évora, 7000-671 Évora, Portugal.; Academic Clinical Center of Alentejo, C-TRAIL, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal.; Department of Medical and Health Sciences, School of Health and Human Development, University of Évora, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal., Burke AJ; LAQV-REQUIMTE, Institute for Research and Advanced Training (IIFA), University of Évora, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal.; Faculty Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.; Departamento de Química, Coimbra Chemistry Centre-Institute of Molecular Sciences (CQC-IMS), University of Coimbra, 3004-535 Coimbra, Portugal.; Center for Neurosciences and Cellular Biology (CNC), Polo I, Universidade de Coimbra Rua Larga Faculdade de Medicina, Polo I, 1ºandar, 3004-504 Coimbra, Portugal., Carreiro EP; LAQV-REQUIMTE, Institute for Research and Advanced Training (IIFA), University of Évora, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal.
Source: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 17; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 17.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
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