Dapagliflozin mitigates cellular stress and inflammation through PI3K/AKT pathway modulation in cardiomyocytes, aortic endothelial cells, and stem cell-derived β cells.
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| Title: | Dapagliflozin mitigates cellular stress and inflammation through PI3K/AKT pathway modulation in cardiomyocytes, aortic endothelial cells, and stem cell-derived β cells. |
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| Authors: | Alsereidi FR; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Emirates Health Services (EHS), Dubai, United Arab Emirates., Khashim Z; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Marzook H; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Al-Rawi AM; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Salomon T; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Almansoori MK; College of Medicine and Health Sciences, United Arab Emirates University, Abu Dhabi, United Arab Emirates., Madkour MM; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Hamam AM; Endocrinology and Metabolism Department, Armed Forces College of Medicine, Cairo, Egypt., Ramadan MM; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Department of Cardiology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt., Peterson QP; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA., Saleh MA; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. mohamed.saleh@sharjah.ac.ae.; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates. mohamed.saleh@sharjah.ac.ae.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. mohamed.saleh@sharjah.ac.ae. |
| Source: | Cardiovascular diabetology [Cardiovasc Diabetol] 2024 Oct 29; Vol. 23 (1), pp. 388. Date of Electronic Publication: 2024 Oct 29. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1475-2840 |
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| DOI: | 10.1186/s12933-024-02481-y |
