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Dapagliflozin mitigates cellular stress and inflammation through PI3K/AKT pathway modulation in cardiomyocytes, aortic endothelial cells, and stem cell-derived β cells.

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Title: Dapagliflozin mitigates cellular stress and inflammation through PI3K/AKT pathway modulation in cardiomyocytes, aortic endothelial cells, and stem cell-derived β cells.
Authors: Alsereidi FR; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Emirates Health Services (EHS), Dubai, United Arab Emirates., Khashim Z; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Marzook H; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Al-Rawi AM; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Salomon T; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Almansoori MK; College of Medicine and Health Sciences, United Arab Emirates University, Abu Dhabi, United Arab Emirates., Madkour MM; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Hamam AM; Endocrinology and Metabolism Department, Armed Forces College of Medicine, Cairo, Egypt., Ramadan MM; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Department of Cardiology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt., Peterson QP; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA., Saleh MA; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. mohamed.saleh@sharjah.ac.ae.; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates. mohamed.saleh@sharjah.ac.ae.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. mohamed.saleh@sharjah.ac.ae.
Source: Cardiovascular diabetology [Cardiovasc Diabetol] 2024 Oct 29; Vol. 23 (1), pp. 388. Date of Electronic Publication: 2024 Oct 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dapagliflozin mitigates cellular stress and inflammation through PI3K/AKT pathway modulation in cardiomyocytes, aortic endothelial cells, and stem cell-derived β cells.
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  Data: <searchLink fieldCode="AU" term="%22Alsereidi+FR%22">Alsereidi FR</searchLink>; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Emirates Health Services (EHS), Dubai, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Khashim+Z%22">Khashim Z</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Marzook+H%22">Marzook H</searchLink>; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Al-Rawi+AM%22">Al-Rawi AM</searchLink>; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Salomon+T%22">Salomon T</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Almansoori+MK%22">Almansoori MK</searchLink>; College of Medicine and Health Sciences, United Arab Emirates University, Abu Dhabi, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Madkour+MM%22">Madkour MM</searchLink>; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Hamam+AM%22">Hamam AM</searchLink>; Endocrinology and Metabolism Department, Armed Forces College of Medicine, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Ramadan+MM%22">Ramadan MM</searchLink>; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Department of Cardiology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.<br /><searchLink fieldCode="AU" term="%22Peterson+QP%22">Peterson QP</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Saleh+MA%22">Saleh MA</searchLink>; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. mohamed.saleh@sharjah.ac.ae.; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates. mohamed.saleh@sharjah.ac.ae.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. mohamed.saleh@sharjah.ac.ae.
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  Data: <searchLink fieldCode="JN" term="%22101147637%22">Cardiovascular diabetology</searchLink> [Cardiovasc Diabetol] 2024 Oct 29; Vol. 23 (1), pp. 388. <i>Date of Electronic Publication: </i>2024 Oct 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101147637 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-2840 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214752840%22">14752840 </searchLink><i>NLM ISO Abbreviation: </i>Cardiovasc Diabetol <i>Subsets: </i>MEDLINE
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