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Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted.

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Title: Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted.
Authors: Governa V; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., de Oliveira KG; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Bång-Rudenstam A; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Offer S; Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg 85764, Germany., Cerezo-Magaña M; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Li J; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Beyer S; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Johansson MC; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Månsson AS; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Edvardsson C; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Durmo F; Division of Diagnostic Radiology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Gustafsson E; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Boukredine A; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Jeannot P; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund, Lund University, Lund 221 00, Sweden., Schmidt K; Infectious Diseases and Immunodeficiency Section, Department of Medicine 3, University Hospital Erlangen, Friedrich-Alexander-University Erlangen, Erlangen 91054, Germany., Gezelius E; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Menard JA; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Garza R; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund 221 00, Sweden., Jakobsson J; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund 221 00, Sweden., de Neergaard T; Division of Infection Medicine, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Sundgren PC; Division of Diagnostic Radiology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.; Lund Bioimaging Centre, Lund University, Lund 221 00, Sweden.; Department of Medical Imaging and Function, Skåne University Hospital, Lund 221 85, Sweden., Tiihonen AM; Prostate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere 33101, Finland., Haapasalo H; Fimlab Laboratories Ltd., Tampere University Hospital, Tampere 33101, Finland., Rautajoki KJ; Prostate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere 33101, Finland., Nordenfelt P; Division of Infection Medicine, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Darabi A; Division of Neurosurgery, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Forsberg-Nilsson K; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 751 85, Sweden.; Biodiscovery Institute, University of Nottingham, Nottingham NG7 2QL, UK.; Science for Life Laboratory, Uppsala 752 37, Sweden., Pietras A; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund, Lund University, Lund 221 00, Sweden., Talbot H; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden., Bengzon J; Division of Neurosurgery, Department of Clinical Sciences, Lund, Lund University Hospital, Lund 221 85, Sweden., Belting M; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.; Department of Hematology, Oncology and Radiophysics, Skåne University Hospital, Lund 221 85, Sweden.
Source: Science translational medicine [Sci Transl Med] 2024 Oct 30; Vol. 16 (771), pp. eadk1168. Date of Electronic Publication: 2024 Oct 30.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted.
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  Data: <searchLink fieldCode="AU" term="%22Governa+V%22">Governa V</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+KG%22">de Oliveira KG</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Bång-Rudenstam+A%22">Bång-Rudenstam A</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Offer+S%22">Offer S</searchLink>; Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg 85764, Germany.<br /><searchLink fieldCode="AU" term="%22Cerezo-Magaña+M%22">Cerezo-Magaña M</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Beyer+S%22">Beyer S</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Johansson+MC%22">Johansson MC</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Månsson+AS%22">Månsson AS</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Edvardsson+C%22">Edvardsson C</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Durmo+F%22">Durmo F</searchLink>; Division of Diagnostic Radiology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Gustafsson+E%22">Gustafsson E</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Boukredine+A%22">Boukredine A</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Jeannot+P%22">Jeannot P</searchLink>; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Schmidt+K%22">Schmidt K</searchLink>; Infectious Diseases and Immunodeficiency Section, Department of Medicine 3, University Hospital Erlangen, Friedrich-Alexander-University Erlangen, Erlangen 91054, Germany.<br /><searchLink fieldCode="AU" term="%22Gezelius+E%22">Gezelius E</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Menard+JA%22">Menard JA</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Garza+R%22">Garza R</searchLink>; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Jakobsson+J%22">Jakobsson J</searchLink>; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22de+Neergaard+T%22">de Neergaard T</searchLink>; Division of Infection Medicine, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Sundgren+PC%22">Sundgren PC</searchLink>; Division of Diagnostic Radiology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.; Lund Bioimaging Centre, Lund University, Lund 221 00, Sweden.; Department of Medical Imaging and Function, Skåne University Hospital, Lund 221 85, Sweden.<br /><searchLink fieldCode="AU" term="%22Tiihonen+AM%22">Tiihonen AM</searchLink>; Prostate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere 33101, Finland.<br /><searchLink fieldCode="AU" term="%22Haapasalo+H%22">Haapasalo H</searchLink>; Fimlab Laboratories Ltd., Tampere University Hospital, Tampere 33101, Finland.<br /><searchLink fieldCode="AU" term="%22Rautajoki+KJ%22">Rautajoki KJ</searchLink>; Prostate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere 33101, Finland.<br /><searchLink fieldCode="AU" term="%22Nordenfelt+P%22">Nordenfelt P</searchLink>; Division of Infection Medicine, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Darabi+A%22">Darabi A</searchLink>; Division of Neurosurgery, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Forsberg-Nilsson+K%22">Forsberg-Nilsson K</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 751 85, Sweden.; Biodiscovery Institute, University of Nottingham, Nottingham NG7 2QL, UK.; Science for Life Laboratory, Uppsala 752 37, Sweden.<br /><searchLink fieldCode="AU" term="%22Pietras+A%22">Pietras A</searchLink>; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Talbot+H%22">Talbot H</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Bengzon+J%22">Bengzon J</searchLink>; Division of Neurosurgery, Department of Clinical Sciences, Lund, Lund University Hospital, Lund 221 85, Sweden.<br /><searchLink fieldCode="AU" term="%22Belting+M%22">Belting M</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.; Department of Hematology, Oncology and Radiophysics, Skåne University Hospital, Lund 221 85, Sweden.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2024 Oct 30; Vol. 16 (771), pp. eadk1168. <i>Date of Electronic Publication: </i>2024 Oct 30.
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