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The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma.

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Title: The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma.
Authors: Sudalagunta PR; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Canevarolo RR; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Meads MB; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Silva M; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Zhao X; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Cubitt CL; Cancer Pharmacokinetics and Pharmacodynamics Core, Moffitt Cancer Center and Research Institute, Tampa, Florida., Sansil SS; Cancer Pharmacokinetics and Pharmacodynamics Core, Moffitt Cancer Center and Research Institute, Tampa, Florida., DeAvila G; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Alugubelli RR; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Bishop RT; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida., Tungesvik A; Department of Internal Medicine, University of South Florida, Tampa, Florida., Zhang Q; Aster Insights (formerly M2Gen), Tampa, Florida., Hampton O; Aster Insights (formerly M2Gen), Tampa, Florida., Teer JK; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center and Research Institute, Tampa, Florida., Welsh EA; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center and Research Institute, Tampa, Florida., Yoder SJ; Molecular Genomics Core, Moffitt Cancer Center and Research Institute, Tampa, Florida., Shah BD; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Hazlehurst L; Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia., Gatenby RA; Department of Radiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.; Department of Integrated Mathematical Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Van Domelen DR; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts., Chai Y; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts., Wang F; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts., DeCastro A; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts., Bloomer AM; Total Cancer Care, Moffitt Cancer Center, Tampa, Florida., Siegel EM; Total Cancer Care, Moffitt Cancer Center, Tampa, Florida., Lynch CC; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida., Sullivan DM; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Alsina M; Department of Blood and Marrow Transplant and Cellular Therapies, Moffitt Cancer Center and Research Institute, Tampa, Florida., Nishihori T; Department of Blood and Marrow Transplant and Cellular Therapies, Moffitt Cancer Center and Research Institute, Tampa, Florida., Brayer J; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Cleveland JL; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida., Dalton W; Molecular Medicine Program, Moffitt Cancer Center and Research Institute, Tampa, Florida., Walker CJ; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts., Landesman Y; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts., Baz R; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Silva AS; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Shain KH; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida.
Source: Cancer research [Cancer Res] 2025 Jan 15; Vol. 85 (2), pp. 378-398.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Sudalagunta+PR%22">Sudalagunta PR</searchLink>; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Canevarolo+RR%22">Canevarolo RR</searchLink>; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Meads+MB%22">Meads MB</searchLink>; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Silva+M%22">Silva M</searchLink>; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Cubitt+CL%22">Cubitt CL</searchLink>; Cancer Pharmacokinetics and Pharmacodynamics Core, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Sansil+SS%22">Sansil SS</searchLink>; Cancer Pharmacokinetics and Pharmacodynamics Core, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22DeAvila+G%22">DeAvila G</searchLink>; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Alugubelli+RR%22">Alugubelli RR</searchLink>; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Bishop+RT%22">Bishop RT</searchLink>; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Tungesvik+A%22">Tungesvik A</searchLink>; Department of Internal Medicine, University of South Florida, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Aster Insights (formerly M2Gen), Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Hampton+O%22">Hampton O</searchLink>; Aster Insights (formerly M2Gen), Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Teer+JK%22">Teer JK</searchLink>; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Welsh+EA%22">Welsh EA</searchLink>; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Yoder+SJ%22">Yoder SJ</searchLink>; Molecular Genomics Core, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Shah+BD%22">Shah BD</searchLink>; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Hazlehurst+L%22">Hazlehurst L</searchLink>; Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia.<br /><searchLink fieldCode="AU" term="%22Gatenby+RA%22">Gatenby RA</searchLink>; Department of Radiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.; Department of Integrated Mathematical Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Van+Domelen+DR%22">Van Domelen DR</searchLink>; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Chai+Y%22">Chai Y</searchLink>; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts.<br /><searchLink fieldCode="AU" term="%22DeCastro+A%22">DeCastro A</searchLink>; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Bloomer+AM%22">Bloomer AM</searchLink>; Total Cancer Care, Moffitt Cancer Center, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Siegel+EM%22">Siegel EM</searchLink>; Total Cancer Care, Moffitt Cancer Center, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Lynch+CC%22">Lynch CC</searchLink>; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Sullivan+DM%22">Sullivan DM</searchLink>; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Alsina+M%22">Alsina M</searchLink>; Department of Blood and Marrow Transplant and Cellular Therapies, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Nishihori+T%22">Nishihori T</searchLink>; Department of Blood and Marrow Transplant and Cellular Therapies, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Brayer+J%22">Brayer J</searchLink>; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Cleveland+JL%22">Cleveland JL</searchLink>; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Dalton+W%22">Dalton W</searchLink>; Molecular Medicine Program, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Walker+CJ%22">Walker CJ</searchLink>; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Landesman+Y%22">Landesman Y</searchLink>; Research and Translational Development, Karyopharm Therapeutics, Newton, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Baz+R%22">Baz R</searchLink>; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Silva+AS%22">Silva AS</searchLink>; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Shain+KH%22">Shain KH</searchLink>; Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, Florida.
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