CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles.
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| Title: | CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles. |
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| Authors: | Jin Y; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, 66047, USA., Basu S; Department of Biological Sciences, Texas Tech University, Lubbock, TX, 79409, USA., Feng M; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, 66047, USA., Ning Y; Department of Biological Sciences, Texas Tech University, Lubbock, TX, 79409, USA., Munasinghe I; Synthetic Chemical Biology Core Laboratory, The University of Kansas, Lawrence, KS, 66047, USA., Joachim AM; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Li J; College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Qin L; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, 66047, USA., Madden R; Department of Biological Sciences, Texas Tech University, Lubbock, TX, 79409, USA., Burks H; Department of Biological Sciences, Texas Tech University, Lubbock, TX, 79409, USA., Gao P; Protein Production Group, The University of Kansas, Lawrence, KS, 66047, USA., Wu JQ; Department of Pharmacy Practice, School of Pharmacy, The University of Kansas, Lawrence, KS, 66047, USA., Sheikh SW; Department of Biological Sciences, Texas Tech University, Lubbock, TX, 79409, USA., Joice AC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Perera C; Synthetic Chemical Biology Core Laboratory, The University of Kansas, Lawrence, KS, 66047, USA., Werbovetz KA; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Zhang K; Department of Biological Sciences, Texas Tech University, Lubbock, TX, 79409, USA., Wang MZ; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, 66047, USA. michael.wang@ku.edu. |
| Source: | Nature communications [Nat Commun] 2024 Oct 31; Vol. 15 (1), pp. 9409. Date of Electronic Publication: 2024 Oct 31. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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