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Synthesis, preclinical assessment, and first-in-human study of [18F]d4-FET for brain tumor imaging.

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Title: Synthesis, preclinical assessment, and first-in-human study of [18F]d4-FET for brain tumor imaging.
Authors: Hou L; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Chen Z; Department of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Chen F; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518025, China., Sheng L; Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Ye W; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Dai Y; Department of Radiotherapy and Oncology, The Affiliated Hospital of Jiangnan University, Wuxi, 214122, China., Guo X; Department of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Dong C; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Li G; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Liao K; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Li Y; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, GA, 30322, USA., Ma J; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Wei H; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Ran W; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Shang J; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Ling X; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Patel JS; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, GA, 30322, USA., Liang SH; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, GA, 30322, USA. steven.liang@emory.edu., Xu H; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. txh@jnu.edu.cn., Wang L; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. l_wang1009@foxmail.com.
Source: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2025 Feb; Vol. 52 (3), pp. 864-875. Date of Electronic Publication: 2024 Nov 01.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthesis, preclinical assessment, and first-in-human study of [<superscript>18</superscript>F]d<subscript>4</subscript>-FET for brain tumor imaging.
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  Data: <searchLink fieldCode="AU" term="%22Hou+L%22">Hou L</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518025, China.<br /><searchLink fieldCode="AU" term="%22Sheng+L%22">Sheng L</searchLink>; Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Ye+W%22">Ye W</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Dai+Y%22">Dai Y</searchLink>; Department of Radiotherapy and Oncology, The Affiliated Hospital of Jiangnan University, Wuxi, 214122, China.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Dong+C%22">Dong C</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Liao+K%22">Liao K</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, GA, 30322, USA.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Wei+H%22">Wei H</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Ran+W%22">Ran W</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Shang+J%22">Shang J</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Ling+X%22">Ling X</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Patel+JS%22">Patel JS</searchLink>; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, GA, 30322, USA.<br /><searchLink fieldCode="AU" term="%22Liang+SH%22">Liang SH</searchLink>; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, GA, 30322, USA. steven.liang@emory.edu.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. txh@jnu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, & Key Laboratory of Basic and Translational Research On Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. l_wang1009@foxmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101140988%22">European journal of nuclear medicine and molecular imaging</searchLink> [Eur J Nucl Med Mol Imaging] 2025 Feb; Vol. 52 (3), pp. 864-875. <i>Date of Electronic Publication: </i>2024 Nov 01.
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              Text: 2025 Feb
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