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Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling.

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Title: Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling.
Authors: Dupuy M; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Gueguinou M; N2COx UMR 1069, University of Tours,INSERM, Tours, France., Postec A; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Brion R; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.; CHU Nantes, Nantes, France., Tesfaye R; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Mullard M; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Regnier L; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Amiaud J; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Hubsch C; UMR CNRS 7021, Translational, Transversal and Therapeutic Oncology (OnKO-3T) Team, University of Strasbourg, Illkirch, France., Potier-Cartereau M; N2COx UMR 1069, University of Tours,INSERM, Tours, France., Chantôme A; N2COx UMR 1069, University of Tours,INSERM, Tours, France., Brounais-Le Royer B; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Baud'huin M; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.; CHU Nantes, Nantes, France., Georges S; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Lamoureux F; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Ory B; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Entz-Werlé N; UMR CNRS 7021, Translational, Transversal and Therapeutic Oncology (OnKO-3T) Team, University of Strasbourg, Illkirch, France.; Pediatric Onco-Hematology Unit, University Hospitals of Strasbourg, Strasbourg, France., Delattre O; INSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center,Institut Curie, Paris, France., Rédini F; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France., Vandier C; N2COx UMR 1069, University of Tours,INSERM, Tours, France., Verrecchia F; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France. franck.verrecchia@univ-nantes.fr.
Source: Oncogene [Oncogene] 2025 Jan; Vol. 44 (2), pp. 79-91. Date of Electronic Publication: 2024 Nov 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling.
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  Data: <searchLink fieldCode="AU" term="%22Dupuy+M%22">Dupuy M</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Gueguinou+M%22">Gueguinou M</searchLink>; N2COx UMR 1069, University of Tours,INSERM, Tours, France.<br /><searchLink fieldCode="AU" term="%22Postec+A%22">Postec A</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Brion+R%22">Brion R</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.; CHU Nantes, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Tesfaye+R%22">Tesfaye R</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Mullard+M%22">Mullard M</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Regnier+L%22">Regnier L</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Amiaud+J%22">Amiaud J</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Hubsch+C%22">Hubsch C</searchLink>; UMR CNRS 7021, Translational, Transversal and Therapeutic Oncology (OnKO-3T) Team, University of Strasbourg, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Potier-Cartereau+M%22">Potier-Cartereau M</searchLink>; N2COx UMR 1069, University of Tours,INSERM, Tours, France.<br /><searchLink fieldCode="AU" term="%22Chantôme+A%22">Chantôme A</searchLink>; N2COx UMR 1069, University of Tours,INSERM, Tours, France.<br /><searchLink fieldCode="AU" term="%22Brounais-Le+Royer+B%22">Brounais-Le Royer B</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Baud'huin+M%22">Baud'huin M</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.; CHU Nantes, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Georges+S%22">Georges S</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Lamoureux+F%22">Lamoureux F</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Ory+B%22">Ory B</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Entz-Werlé+N%22">Entz-Werlé N</searchLink>; UMR CNRS 7021, Translational, Transversal and Therapeutic Oncology (OnKO-3T) Team, University of Strasbourg, Illkirch, France.; Pediatric Onco-Hematology Unit, University Hospitals of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Delattre+O%22">Delattre O</searchLink>; INSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center,Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Rédini+F%22">Rédini F</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Vandier+C%22">Vandier C</searchLink>; N2COx UMR 1069, University of Tours,INSERM, Tours, France.<br /><searchLink fieldCode="AU" term="%22Verrecchia+F%22">Verrecchia F</searchLink>; Nantes Université, INSERM UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France. franck.verrecchia@univ-nantes.fr.
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