Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells.

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Title: Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells.
Authors: Bédard-Matteau J; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada., Soulé A; Department of Electrical and Computer Engineering, McGill University, Montréal, QC, Canada., Liu KY; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada., Fourcade L; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada., Fraser DD; Children's Health Research Institute & Lawson Health Research Institute, London, ON, Canada.; Department of Pediatrics, Western University, London, ON, Canada., Emad A; Department of Electrical and Computer Engineering, McGill University, Montréal, QC, Canada.; Mila, Quebec AI Institute, Montréal, QC, Canada., Rousseau S; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.
Source: Frontiers in immunology [Front Immunol] 2024 Oct 18; Vol. 15, pp. 1452788. Date of Electronic Publication: 2024 Oct 18 (Print Publication: 2024).
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells.
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  Data: <searchLink fieldCode="AU" term="%22Bédard-Matteau+J%22">Bédard-Matteau J</searchLink>; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Soulé+A%22">Soulé A</searchLink>; Department of Electrical and Computer Engineering, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+KY%22">Liu KY</searchLink>; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Fourcade+L%22">Fourcade L</searchLink>; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Fraser+DD%22">Fraser DD</searchLink>; Children's Health Research Institute & Lawson Health Research Institute, London, ON, Canada.; Department of Pediatrics, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Emad+A%22">Emad A</searchLink>; Department of Electrical and Computer Engineering, McGill University, Montréal, QC, Canada.; Mila, Quebec AI Institute, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Rousseau+S%22">Rousseau S</searchLink>; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2024 Oct 18; Vol. 15, pp. 1452788. <i>Date of Electronic Publication: </i>2024 Oct 18 (<i>Print Publication: </i>2024).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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