Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells.
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| Title: | Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells. |
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| Authors: | Bédard-Matteau J; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada., Soulé A; Department of Electrical and Computer Engineering, McGill University, Montréal, QC, Canada., Liu KY; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada., Fourcade L; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada., Fraser DD; Children's Health Research Institute & Lawson Health Research Institute, London, ON, Canada.; Department of Pediatrics, Western University, London, ON, Canada., Emad A; Department of Electrical and Computer Engineering, McGill University, Montréal, QC, Canada.; Mila, Quebec AI Institute, Montréal, QC, Canada., Rousseau S; The Meakins-Christie Laboratories, Research Institute of the McGill University Heath Centre, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada. |
| Source: | Frontiers in immunology [Front Immunol] 2024 Oct 18; Vol. 15, pp. 1452788. Date of Electronic Publication: 2024 Oct 18 (Print Publication: 2024). |
| Publication Type: | Journal Article; Observational Study |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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