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Deferiprone in Alzheimer Disease: A Randomized Clinical Trial.

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Title: Deferiprone in Alzheimer Disease: A Randomized Clinical Trial.
Authors: Ayton S; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia., Barton D; NeuroCentrix, Carlton, Australia., Brew B; Department of Neurology and Peter Duncan Neurosciences Research Unit, St Vincent's Hospital, Darlinghurst, Australia.; University of New South Wales, Sydney, Australia., Brodtmann A; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia., Clarnette R; Curtin Health Innovation Research Institute, Curtin University, Bentley, Australia., Desmond P; Department of Radiology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Australia., Devos D; Department of Medical Pharmacology, Expert Center of Parkinson's Disease, ALS, and Neurogenetics, University of Lille, Lille Neuroscience & Cognition Research Center, Lille, France., Ellis KA; Department of Psychiatry, Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Australia., Fazlollahi A; Department of Radiology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, Australia., Fradette C; Chiesi Global Rare Diseases, Chiesi Canada Corporation, Woodbridge, Canada., Goh AMY; National Ageing Research Institute, The University of Melbourne, Parkville, Australia., Kalinowski P; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia., Kyndt C; Melbourne Health Cognitive Neurology Clinic, The Royal Melbourne Hospital, Parkville, Australia., Lai R; KaRa Institute of Neurological Diseases, Macquarie Park, Australia., Lim YY; School of Psychological Sciences, Monash University, Melbourne, Australia.; Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia., Maruff P; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; Cogstate Ltd, Melbourne, Australia., O'Brien TJ; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia., Rowe C; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; Austin Health, The University of Melbourne, Parkville, Australia., Salvado O; Data61, Commonwealth Scientific and Industrial Research Organization, Eveleigh, Australia., Schofield PW; Neuropsychiatry Service, Hunter New England Local Health District, Newcastle, Australia.; University of Newcastle, Callaghan, Australia., Spino M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada., Tricta F; Chiesi Global Rare Diseases, Chiesi Canada Corporation, Woodbridge, Canada., Wagen A; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, United Kingdom.; The Francis Crick Institute, London, United Kingdom.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Williams R; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; National Imaging Facility, St Lucia, Australia., Woodward M; Austin Health, The University of Melbourne, Parkville, Australia., Bush AI; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.
Source: JAMA neurology [JAMA Neurol] 2025 Jan 01; Vol. 82 (1), pp. 11-18.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deferiprone in Alzheimer Disease: A Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Ayton+S%22">Ayton S</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Barton+D%22">Barton D</searchLink>; NeuroCentrix, Carlton, Australia.<br /><searchLink fieldCode="AU" term="%22Brew+B%22">Brew B</searchLink>; Department of Neurology and Peter Duncan Neurosciences Research Unit, St Vincent's Hospital, Darlinghurst, Australia.; University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Brodtmann+A%22">Brodtmann A</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Clarnette+R%22">Clarnette R</searchLink>; Curtin Health Innovation Research Institute, Curtin University, Bentley, Australia.<br /><searchLink fieldCode="AU" term="%22Desmond+P%22">Desmond P</searchLink>; Department of Radiology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Devos+D%22">Devos D</searchLink>; Department of Medical Pharmacology, Expert Center of Parkinson's Disease, ALS, and Neurogenetics, University of Lille, Lille Neuroscience & Cognition Research Center, Lille, France.<br /><searchLink fieldCode="AU" term="%22Ellis+KA%22">Ellis KA</searchLink>; Department of Psychiatry, Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Fazlollahi+A%22">Fazlollahi A</searchLink>; Department of Radiology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Fradette+C%22">Fradette C</searchLink>; Chiesi Global Rare Diseases, Chiesi Canada Corporation, Woodbridge, Canada.<br /><searchLink fieldCode="AU" term="%22Goh+AMY%22">Goh AMY</searchLink>; National Ageing Research Institute, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Kalinowski+P%22">Kalinowski P</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Kyndt+C%22">Kyndt C</searchLink>; Melbourne Health Cognitive Neurology Clinic, The Royal Melbourne Hospital, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Lai+R%22">Lai R</searchLink>; KaRa Institute of Neurological Diseases, Macquarie Park, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+YY%22">Lim YY</searchLink>; School of Psychological Sciences, Monash University, Melbourne, Australia.; Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Maruff+P%22">Maruff P</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; Cogstate Ltd, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22O'Brien+TJ%22">O'Brien TJ</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Rowe+C%22">Rowe C</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; Austin Health, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Salvado+O%22">Salvado O</searchLink>; Data61, Commonwealth Scientific and Industrial Research Organization, Eveleigh, Australia.<br /><searchLink fieldCode="AU" term="%22Schofield+PW%22">Schofield PW</searchLink>; Neuropsychiatry Service, Hunter New England Local Health District, Newcastle, Australia.; University of Newcastle, Callaghan, Australia.<br /><searchLink fieldCode="AU" term="%22Spino+M%22">Spino M</searchLink>; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Tricta+F%22">Tricta F</searchLink>; Chiesi Global Rare Diseases, Chiesi Canada Corporation, Woodbridge, Canada.<br /><searchLink fieldCode="AU" term="%22Wagen+A%22">Wagen A</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, United Kingdom.; The Francis Crick Institute, London, United Kingdom.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Williams+R%22">Williams R</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; National Imaging Facility, St Lucia, Australia.<br /><searchLink fieldCode="AU" term="%22Woodward+M%22">Woodward M</searchLink>; Austin Health, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Bush+AI%22">Bush AI</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.
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