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Effects of Cimetidine and Dolutegravir on the Endogenous Drug-Drug Interaction Biomarkers for Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Protein 1 in Healthy Volunteers.

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Title: Effects of Cimetidine and Dolutegravir on the Endogenous Drug-Drug Interaction Biomarkers for Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Protein 1 in Healthy Volunteers.
Authors: Koishikawa T; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan., Fujiwara K; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan., Taskar K; Drug Metabolism and Pharmacokinetic, GSK, Stevenage, UK., Zamek-Gliszczynski MJ; Drug Metabolism and Pharmacokinetic, GSK, Collegeville, Pennsylvania, USA., Yoshida K; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Chu X; Department of Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics, Merck & Co., Inc., Rahway, New Jersey, USA., Hirabayashi H; Center of Excellence for Drug Metabolism, Pharmacokinetics and Modeling, Preclinical and Translational Sciences, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan., Mao J; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA., Rockich K; Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Incyte Research Institute, Wilmington, Delaware, USA., Takashima T; Laboratory for Safety Assessment & ADME, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, Shizuoka, Japan., Yamaura Y; Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka, Japan., Lai Y; Drug Metabolism Department, Gilead Sciences Inc., Foster City, California, USA., Tomoda Y; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan., Kito T; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan., Maeda K; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan.; Faculty of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan., Furihata K; P-One Clinic, Keikokai Medical Corp, Tokyo, Japan., Sugiyama Y; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Yokohama, Kanagawa, Japan., Kusuhara H; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2025 Feb; Vol. 117 (2), pp. 523-533. Date of Electronic Publication: 2024 Nov 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effects of Cimetidine and Dolutegravir on the Endogenous Drug-Drug Interaction Biomarkers for Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Protein 1 in Healthy Volunteers.
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  Data: <searchLink fieldCode="AU" term="%22Koishikawa+T%22">Koishikawa T</searchLink>; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan.<br /><searchLink fieldCode="AU" term="%22Fujiwara+K%22">Fujiwara K</searchLink>; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan.<br /><searchLink fieldCode="AU" term="%22Taskar+K%22">Taskar K</searchLink>; Drug Metabolism and Pharmacokinetic, GSK, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Zamek-Gliszczynski+MJ%22">Zamek-Gliszczynski MJ</searchLink>; Drug Metabolism and Pharmacokinetic, GSK, Collegeville, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Yoshida+K%22">Yoshida K</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Chu+X%22">Chu X</searchLink>; Department of Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics, Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Hirabayashi+H%22">Hirabayashi H</searchLink>; Center of Excellence for Drug Metabolism, Pharmacokinetics and Modeling, Preclinical and Translational Sciences, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Mao+J%22">Mao J</searchLink>; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Rockich+K%22">Rockich K</searchLink>; Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Incyte Research Institute, Wilmington, Delaware, USA.<br /><searchLink fieldCode="AU" term="%22Takashima+T%22">Takashima T</searchLink>; Laboratory for Safety Assessment & ADME, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamaura+Y%22">Yamaura Y</searchLink>; Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Lai+Y%22">Lai Y</searchLink>; Drug Metabolism Department, Gilead Sciences Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Tomoda+Y%22">Tomoda Y</searchLink>; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan.<br /><searchLink fieldCode="AU" term="%22Kito+T%22">Kito T</searchLink>; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan.<br /><searchLink fieldCode="AU" term="%22Maeda+K%22">Maeda K</searchLink>; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan.; Faculty of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Furihata+K%22">Furihata K</searchLink>; P-One Clinic, Keikokai Medical Corp, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sugiyama+Y%22">Sugiyama Y</searchLink>; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Kusuhara+H%22">Kusuhara H</searchLink>; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo City, Japan.
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