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Bioinformatic workflows for deriving transcriptomic points of departure: current status, data gaps, and research priorities.

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Title: Bioinformatic workflows for deriving transcriptomic points of departure: current status, data gaps, and research priorities.
Authors: O'Brien J; Ecotoxicology and Wildlife Health Division, Environment and Climate Change Canada, Ottawa, ON J8X 4C6, Canada., Mitchell C; Health and Environmental Sciences Institute, Washington, DC 22205, United States., Auerbach S; Predictive Toxicology Branch, Division of Translational Toxicology, NIEHS, Research Triangle Park, NC 27709, United States., Doonan L; Syngenta International Research Centre, Berkshire RG42 6EY, United Kingdom., Ewald J; Institute of Parasitology, McGill University, Montreal, QC H3A 0G4, Canada., Everett L; Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27709, United States., Faranda A; FMC Agricultural Solutions, Newark, DE 19711, United States., Johnson K; Corteva Agriscience, Indianapolis, IN 46268, United States., Reardon A; Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON K1A 0K9, Canada.; Existing Substances Risk Assessment Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada., Rooney J; Syngenta Crop Protection, LLC, Greensboro, NC 27409, United States., Shao K; Department of Environmental and Occupational Health, School of Public Health-Bloomington, Indiana University, Bloomington, IN 47405, United States., Stainforth R; Radiation Protection Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada., Wheeler M; Predictive Toxicology Branch, Division of Translational Toxicology, NIEHS, Research Triangle Park, NC 27709, United States., Dalmas Wilk D; Investigative Safety, GSK, Collegeville, PA 19426, United States., Williams A; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada., Yauk C; Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Costa E; Corteva Agriscience, 71 Mogi Mirim, Brazil.
Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2025 Feb 01; Vol. 203 (2), pp. 147-159.
Publication Type: Journal Article; Review
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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