Systematic analysis of natural topoisomerase I inhibitors from Forsythiae Fructus by ultrafiltration-UPLC-ESI-MS/MS, pharmacophore modelling, and molecular dynamics simulation.

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Title: Systematic analysis of natural topoisomerase I inhibitors from Forsythiae Fructus by ultrafiltration-UPLC-ESI-MS/MS, pharmacophore modelling, and molecular dynamics simulation.
Authors: Wang T; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China., Tan N; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China., Lu J; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China., Li Z; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China., Wang H; College of Computer Science and Technology, Baoji University of Arts and Sciences, Baoji, China., Hu J; College of Electronic and Electrical Engineering, Baoji University of Arts and Sciences, Baoji, China., Zhang S; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China., Qi J; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A & F University, Yangling, China., Wang X; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China., Wang L; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China.
Source: Natural product research [Nat Prod Res] 2026 Mar; Vol. 40 (5), pp. 1327-1337. Date of Electronic Publication: 2024 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Systematic analysis of natural topoisomerase I inhibitors from Forsythiae Fructus by ultrafiltration-UPLC-ESI-MS/MS, pharmacophore modelling, and molecular dynamics simulation.
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  Data: <searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China.<br /><searchLink fieldCode="AU" term="%22Tan+N%22">Tan N</searchLink>; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; College of Computer Science and Technology, Baoji University of Arts and Sciences, Baoji, China.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; College of Electronic and Electrical Engineering, Baoji University of Arts and Sciences, Baoji, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A & F University, Yangling, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China.
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              Text: 2026 Mar
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