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Unsupervised Classification of the Host Response Identifies Dominant Pathobiological Signatures of Sepsis in Sub-Saharan Africa.

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Title: Unsupervised Classification of the Host Response Identifies Dominant Pathobiological Signatures of Sepsis in Sub-Saharan Africa.
Authors: Cummings MJ; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.; Center for Infection and Immunity., Lutwama JJ; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and., Owor N; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and., Tomoiaga AS; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.; Department of Accounting, Business Analytics, Computer Information Systems, and Law, Manhattan College, New York, New York., Ross JE; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine., Muwanga M; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda., Nsereko C; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda., Nayiga I; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda., Kyebambe S; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda., Shinyale J; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda., Ochar T; Tororo General Hospital, Ministry of Health, Tororo, Uganda., Kiwubeyi M; Tororo General Hospital, Ministry of Health, Tororo, Uganda., Nankwanga R; Tororo General Hospital, Ministry of Health, Tororo, Uganda., Nie K; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Xie H; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Miake-Lye S; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Villagomez B; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Qi J; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Reynolds SJ; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Rakai Health Sciences Program, Kalisizo, Uganda; and., Nakibuuka MC; Rakai Health Sciences Program, Kalisizo, Uganda; and., Lu X; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine., Kayiwa J; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and., Haumba M; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and., Nakaseegu J; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and., Che X; Center for Infection and Immunity.; Department of Biostatistics, and., Wayengera M; Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda., Ghosh S; Department of Microbiology and Immunology, and., Kim-Schulze S; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Lipkin WI; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons.; Center for Infection and Immunity.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York., Bakamutumaho B; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.; Immunizable Diseases Unit, Uganda Virus Research Institute, Entebbe, Uganda., O'Donnell MR; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.; Center for Infection and Immunity.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2025 Mar; Vol. 211 (3), pp. 357-369.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
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  Data: Unsupervised Classification of the Host Response Identifies Dominant Pathobiological Signatures of Sepsis in Sub-Saharan Africa.
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Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda.<br /><searchLink fieldCode="AU" term="%22Nsereko+C%22">Nsereko C</searchLink>; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda.<br /><searchLink fieldCode="AU" term="%22Nayiga+I%22">Nayiga I</searchLink>; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda.<br /><searchLink fieldCode="AU" term="%22Kyebambe+S%22">Kyebambe S</searchLink>; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda.<br /><searchLink fieldCode="AU" term="%22Shinyale+J%22">Shinyale J</searchLink>; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda.<br /><searchLink fieldCode="AU" term="%22Ochar+T%22">Ochar T</searchLink>; Tororo General Hospital, Ministry of Health, Tororo, Uganda.<br /><searchLink fieldCode="AU" term="%22Kiwubeyi+M%22">Kiwubeyi M</searchLink>; Tororo General Hospital, Ministry of Health, Tororo, Uganda.<br /><searchLink fieldCode="AU" term="%22Nankwanga+R%22">Nankwanga R</searchLink>; 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Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Rakai Health Sciences Program, Kalisizo, Uganda; and.<br /><searchLink fieldCode="AU" term="%22Nakibuuka+MC%22">Nakibuuka MC</searchLink>; Rakai Health Sciences Program, Kalisizo, Uganda; and.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.<br /><searchLink fieldCode="AU" term="%22Kayiwa+J%22">Kayiwa J</searchLink>; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.<br /><searchLink fieldCode="AU" term="%22Haumba+M%22">Haumba M</searchLink>; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.<br /><searchLink fieldCode="AU" term="%22Nakaseegu+J%22">Nakaseegu J</searchLink>; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.<br /><searchLink fieldCode="AU" term="%22Che+X%22">Che X</searchLink>; 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Immunizable Diseases Unit, Uganda Virus Research Institute, Entebbe, Uganda.<br /><searchLink fieldCode="AU" term="%22O'Donnell+MR%22">O'Donnell MR</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.; Center for Infection and Immunity.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
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