Dabigatran attenuates methotrexate-induced hepatotoxicity by regulating coagulation, endothelial dysfunction, and the NF-kB/IL-1β/MCP-1 and TLR4/NLRP3 signaling pathways.
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| Title: | Dabigatran attenuates methotrexate-induced hepatotoxicity by regulating coagulation, endothelial dysfunction, and the NF-kB/IL-1β/MCP-1 and TLR4/NLRP3 signaling pathways. |
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| Authors: | El-Dessouki AM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University (ACU), 6th of October City, 12566, Giza, Egypt. ahmed.desoky@acu.edu.eg., Alzokaky AA; Pharmacology and Toxicology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11651, Egypt.; Pharmacology and Biochemistry Department, Faculty of Pharmacy, Horus University, New Damietta, 34518, Egypt., Raslan NA; Pharmacology and Toxicology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11651, Egypt.; Clinical Pharmacy Department, College of Health Sciences and Nursing, Al-Rayan Colleges, AL-Madinah AL-Munawarah, Saudi Arabia., Ibrahim S; Pharmacy Practice and Clinical Pharmacy Department, Faculty of Pharmacy, Galala University-Ataka, Suez, Egypt., Selim HMRM; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, 11597, Riyadh, Saudi Arabia., Al-Karmalawy AA; Department of Pharmaceutical Chemistry, College of Pharmacy, The University of Mashreq, Baghdad, 10023, Iraq. akarmalawy@horus.edu.eg.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University, New Damietta, 34518, Egypt. akarmalawy@horus.edu.eg. |
| Source: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 May; Vol. 398 (5), pp. 5129-5145. Date of Electronic Publication: 2024 Nov 11. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39527308 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dabigatran attenuates methotrexate-induced hepatotoxicity by regulating coagulation, endothelial dysfunction, and the NF-kB/IL-1β/MCP-1 and TLR4/NLRP3 signaling pathways. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22El-Dessouki+AM%22">El-Dessouki AM</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University (ACU), 6th of October City, 12566, Giza, Egypt. ahmed.desoky@acu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Alzokaky+AA%22">Alzokaky AA</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11651, Egypt.; Pharmacology and Biochemistry Department, Faculty of Pharmacy, Horus University, New Damietta, 34518, Egypt.<br /><searchLink fieldCode="AU" term="%22Raslan+NA%22">Raslan NA</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11651, Egypt.; Clinical Pharmacy Department, College of Health Sciences and Nursing, Al-Rayan Colleges, AL-Madinah AL-Munawarah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ibrahim+S%22">Ibrahim S</searchLink>; Pharmacy Practice and Clinical Pharmacy Department, Faculty of Pharmacy, Galala University-Ataka, Suez, Egypt.<br /><searchLink fieldCode="AU" term="%22Selim+HMRM%22">Selim HMRM</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, 11597, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al-Karmalawy+AA%22">Al-Karmalawy AA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, The University of Mashreq, Baghdad, 10023, Iraq. akarmalawy@horus.edu.eg.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University, New Damietta, 34518, Egypt. akarmalawy@horus.edu.eg. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220326264%22">Naunyn-Schmiedeberg's archives of pharmacology</searchLink> [Naunyn Schmiedebergs Arch Pharmacol] 2025 May; Vol. 398 (5), pp. 5129-5145. <i>Date of Electronic Publication: </i>2024 Nov 11. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0326264 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1912 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200281298%22">00281298 </searchLink><i>NLM ISO Abbreviation: </i>Naunyn Schmiedebergs Arch Pharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39527308 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00210-024-03567-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 5129 Titles: – TitleFull: Dabigatran attenuates methotrexate-induced hepatotoxicity by regulating coagulation, endothelial dysfunction, and the NF-kB/IL-1β/MCP-1 and TLR4/NLRP3 signaling pathways. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: El-Dessouki AM – PersonEntity: Name: NameFull: Alzokaky AA – PersonEntity: Name: NameFull: Raslan NA – PersonEntity: Name: NameFull: Ibrahim S – PersonEntity: Name: NameFull: Selim HMRM – PersonEntity: Name: NameFull: Al-Karmalawy AA IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2025 May Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1432-1912 Numbering: – Type: volume Value: 398 – Type: issue Value: 5 Titles: – TitleFull: Naunyn-Schmiedeberg's archives of pharmacology Type: main |
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