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Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.

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Title: Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.
Authors: Guo JL; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: guojing84@hotmail.com., Braun D; Denali Therapeutics Inc., South San Francisco, CA, USA., Fitzgerald GA; Denali Therapeutics Inc., South San Francisco, CA, USA., Hsieh YT; Denali Therapeutics Inc., South San Francisco, CA, USA., Rougé L; Denali Therapeutics Inc., South San Francisco, CA, USA., Litvinchuk A; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Steffek M; Denali Therapeutics Inc., South San Francisco, CA, USA., Propson NE; Denali Therapeutics Inc., South San Francisco, CA, USA., Heffner CM; Denali Therapeutics Inc., South San Francisco, CA, USA., Discenza C; Denali Therapeutics Inc., South San Francisco, CA, USA., Han SJ; Denali Therapeutics Inc., South San Francisco, CA, USA., Rana A; Denali Therapeutics Inc., South San Francisco, CA, USA., Skuja LL; Denali Therapeutics Inc., South San Francisco, CA, USA., Lin BQ; Denali Therapeutics Inc., South San Francisco, CA, USA., Sun EW; Denali Therapeutics Inc., South San Francisco, CA, USA., Davis SS; Denali Therapeutics Inc., South San Francisco, CA, USA., Balasundar S; Denali Therapeutics Inc., South San Francisco, CA, USA., Becerra I; Denali Therapeutics Inc., South San Francisco, CA, USA., Dugas JC; Denali Therapeutics Inc., South San Francisco, CA, USA., Ha C; Denali Therapeutics Inc., South San Francisco, CA, USA., Hsiao-Nakamoto J; Denali Therapeutics Inc., South San Francisco, CA, USA., Huang F; Denali Therapeutics Inc., South San Francisco, CA, USA., Jain S; Denali Therapeutics Inc., South San Francisco, CA, USA., Kung JE; Denali Therapeutics Inc., South San Francisco, CA, USA., Liau NPD; Denali Therapeutics Inc., South San Francisco, CA, USA., Mahon CS; Denali Therapeutics Inc., South San Francisco, CA, USA., Nguyen HN; Denali Therapeutics Inc., South San Francisco, CA, USA., Nguyen N; Denali Therapeutics Inc., South San Francisco, CA, USA., Samaddar M; Denali Therapeutics Inc., South San Francisco, CA, USA., Shi Y; Denali Therapeutics Inc., South San Francisco, CA, USA., Tatarakis D; Denali Therapeutics Inc., South San Francisco, CA, USA., Tian Y; Denali Therapeutics Inc., South San Francisco, CA, USA., Zhu Y; Denali Therapeutics Inc., South San Francisco, CA, USA., Suh JH; Denali Therapeutics Inc., South San Francisco, CA, USA., Sandmann T; Denali Therapeutics Inc., South San Francisco, CA, USA., Calvert MEK; Denali Therapeutics Inc., South San Francisco, CA, USA., Arguello A; Denali Therapeutics Inc., South San Francisco, CA, USA., Kane LA; Denali Therapeutics Inc., South San Francisco, CA, USA., Lewcock JW; Denali Therapeutics Inc., South San Francisco, CA, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Koth CM; Denali Therapeutics Inc., South San Francisco, CA, USA., Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: dipaolo@dnli.com.
Source: Cell [Cell] 2025 Jan 09; Vol. 188 (1), pp. 187-206.e26. Date of Electronic Publication: 2024 Nov 11.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.
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Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Discenza+C%22">Discenza C</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Han+SJ%22">Han SJ</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rana+A%22">Rana A</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Skuja+LL%22">Skuja LL</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+BQ%22">Lin BQ</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sun+EW%22">Sun EW</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Davis+SS%22">Davis SS</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Balasundar+S%22">Balasundar S</searchLink>; 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Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mahon+CS%22">Mahon CS</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+HN%22">Nguyen HN</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+N%22">Nguyen N</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Samaddar+M%22">Samaddar M</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tatarakis+D%22">Tatarakis D</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Suh+JH%22">Suh JH</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sandmann+T%22">Sandmann T</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Calvert+MEK%22">Calvert MEK</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Arguello+A%22">Arguello A</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kane+LA%22">Kane LA</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lewcock+JW%22">Lewcock JW</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Holtzman+DM%22">Holtzman DM</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Koth+CM%22">Koth CM</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Di+Paolo+G%22">Di Paolo G</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: dipaolo@dnli.com.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2025 Jan 09; Vol. 188 (1), pp. 187-206.e26. <i>Date of Electronic Publication: </i>2024 Nov 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0413066 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4172 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200928674%22">00928674 </searchLink><i>NLM ISO Abbreviation: </i>Cell <i>Subsets: </i>MEDLINE
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