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A Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway.

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Title: A Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway.
Authors: Steiner WP; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Iverson N; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Liu G; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Venkatakrishnan V; Department of Chemistry, Pennsylvania State University, University Park, PA, USA., Wu J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Stepniewski TM; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) - Pompeu Fabra University (UPF), Dr Aiguader 88, Barcelona, Spain.; InterAx Biotech AG, Villigen, Switzerland., Michaelson Z; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Bröckel JW; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Zhu JF; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Bruystens J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Lee A; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Nelson I; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Bertinetti D; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Arveseth CD; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Tan G; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Spaltenstein P; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Xu J; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Hüttenhain R; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Kay M; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Herberg FW; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Cao E; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Selent J; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) - Pompeu Fabra University (UPF), Dr Aiguader 88, Barcelona, Spain., Anand GS; Department of Chemistry, Pennsylvania State University, University Park, PA, USA.; The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA., Dunbrack RL Jr; Institute for Cancer Research. Fox Chase Cancer Center. Philadelphia PA, USA., Taylor SS; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Myers BR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 27. Date of Electronic Publication: 2025 May 27.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway.
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  Data: <searchLink fieldCode="AU" term="%22Steiner+WP%22">Steiner WP</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Iverson+N%22">Iverson N</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Liu+G%22">Liu G</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Venkatakrishnan+V%22">Venkatakrishnan V</searchLink>; Department of Chemistry, Pennsylvania State University, University Park, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Stepniewski+TM%22">Stepniewski TM</searchLink>; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) - Pompeu Fabra University (UPF), Dr Aiguader 88, Barcelona, Spain.; InterAx Biotech AG, Villigen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Michaelson+Z%22">Michaelson Z</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Bröckel+JW%22">Bröckel JW</searchLink>; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Zhu+JF%22">Zhu JF</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Bruystens+J%22">Bruystens J</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+A%22">Lee A</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+I%22">Nelson I</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Bertinetti+D%22">Bertinetti D</searchLink>; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Arveseth+CD%22">Arveseth CD</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Tan+G%22">Tan G</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Spaltenstein+P%22">Spaltenstein P</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hüttenhain+R%22">Hüttenhain R</searchLink>; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kay+M%22">Kay M</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Herberg+FW%22">Herberg FW</searchLink>; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Cao+E%22">Cao E</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Selent+J%22">Selent J</searchLink>; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) - Pompeu Fabra University (UPF), Dr Aiguader 88, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Anand+GS%22">Anand GS</searchLink>; Department of Chemistry, Pennsylvania State University, University Park, PA, USA.; The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dunbrack+RL+Jr%22">Dunbrack RL Jr</searchLink>; Institute for Cancer Research. Fox Chase Cancer Center. Philadelphia PA, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+SS%22">Taylor SS</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Myers+BR%22">Myers BR</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.
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