Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.

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Title: Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
Authors: Lay AC; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Tran VDT; Vital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Nair V; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Betin V; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Hurcombe JA; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Barrington AF; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Pope RJ; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Burdet F; Vital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Mehl F; Vital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Kryvokhyzha D; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden., Ahmad A; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden., Sinton MC; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Lewis P; Proteomics Facility, University of Bristol, Bristol, UK., Wilson MC; Proteomics Facility, University of Bristol, Bristol, UK., Menon R; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Otto E; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Heesom KJ; Proteomics Facility, University of Bristol, Bristol, UK., Ibberson M; Vital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Looker HC; Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ, USA., Nelson RG; Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ, USA., Ju W; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Kretzler M; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Satchell SC; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Gomez MF; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden., Coward RJM; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK. Richard.Coward@bristol.ac.uk.
Corporate Authors: BEAt-DKD consortium
Source: Nature communications [Nat Commun] 2024 Nov 19; Vol. 15 (1), pp. 10018. Date of Electronic Publication: 2024 Nov 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
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  Data: <searchLink fieldCode="AU" term="%22Lay+AC%22">Lay AC</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Tran+VDT%22">Tran VDT</searchLink>; Vital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Nair+V%22">Nair V</searchLink>; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Betin+V%22">Betin V</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Hurcombe+JA%22">Hurcombe JA</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Barrington+AF%22">Barrington AF</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Pope+RJ%22">Pope RJ</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Burdet+F%22">Burdet F</searchLink>; Vital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mehl+F%22">Mehl F</searchLink>; Vital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kryvokhyzha+D%22">Kryvokhyzha D</searchLink>; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Ahmad+A%22">Ahmad A</searchLink>; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Sinton+MC%22">Sinton MC</searchLink>; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Lewis+P%22">Lewis P</searchLink>; Proteomics Facility, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Wilson+MC%22">Wilson MC</searchLink>; Proteomics Facility, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Menon+R%22">Menon R</searchLink>; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Otto+E%22">Otto E</searchLink>; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Heesom+KJ%22">Heesom KJ</searchLink>; Proteomics Facility, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Ibberson+M%22">Ibberson M</searchLink>; Vital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Looker+HC%22">Looker HC</searchLink>; Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+RG%22">Nelson RG</searchLink>; Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Ju+W%22">Ju W</searchLink>; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Kretzler+M%22">Kretzler M</searchLink>; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Satchell+SC%22">Satchell SC</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Gomez+MF%22">Gomez MF</searchLink>; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Coward+RJM%22">Coward RJM</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK. Richard.Coward@bristol.ac.uk.
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