Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes.

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Title: Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes.
Authors: Cai W; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Liu X; National Institute of Biological Science, Beijing, China., Barajas S; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Xiao S; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Vemula S; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Chen H; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Hematology and Oncology, Chongqing University Three Gorges Hospital, Chongqing, China., Yang Y; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Medical Genetics, School of Basic Medical Sciences, Peking University, Beijing, China., Bochers C; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Henley D; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Liu S; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Jia Y; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Hong M; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Mays TM; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Capitano ML; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Liu H; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA., Ji P; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Gao Z; Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, PA, 17033, USA., Pasini D; European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, 20139, Milan, Italy.; University of Milan, Department of Health Sciences, Via A. di Rudinì 8, 20142, Milan, Italy., Wan J; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Yue F; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA.; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Platanias LC; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA., Xi R; National Institute of Biological Science, Beijing, China., Chen S; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. sisichen@shsmu.edu.cn.; Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. sisichen@shsmu.edu.cn., Liu Y; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. yan.liu@northwestern.edu.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. yan.liu@northwestern.edu.; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA. yan.liu@northwestern.edu.
Source: Leukemia [Leukemia] 2025 Feb; Vol. 39 (2), pp. 296-307. Date of Electronic Publication: 2024 Nov 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5551
DOI:10.1038/s41375-024-02462-w