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Lewy pathology formation in patient-derived GBA1 Parkinson's disease midbrain organoids.

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Title: Lewy pathology formation in patient-derived GBA1 Parkinson's disease midbrain organoids.
Authors: Frattini E; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy., Faustini G; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy., Lopez G; Division of Pathology, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan 20122, Italy., Carsana EV; Department of Medical Biotechnology and Translational Medicine, University of Milano, Milan 20054, Italy., Tosi M; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy., Trezzi I; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy., Magni M; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy., Soldà G; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan 20072, Italy.; Medical Genetics and RNA Biology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan 20089, Italy., Straniero L; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan 20072, Italy.; Medical Genetics and RNA Biology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan 20089, Italy., Facchi D; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan 20072, Italy.; Medical Genetics and RNA Biology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan 20089, Italy., Samarani M; Unité de Trafic Membranaire et Pathogénèse, Département de Biologie Cellulaire et de l'Infection, Institut Pasteur, Paris 75015, France., Martá-Ariza M; Center for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, NY 10016, USA.; Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona 08193, Spain., De Luca CMG; Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan 20133, Italy., Vezzoli E; Advanced Light and Electron Microscopy BioImaging Centre (ALEMBIC), IRCCS San Raffaele Scientific Institute, Milan 20132, Italy., Pittaro A; Division of Pathology, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan 20122, Italy., Stepanyan A; Unità Operativa Complessa, Chirurgia Generale 3, University Hospital of Padua, Padua 35128, Italy., Silipigni R; Laboratory of Medical Genetics, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy., Rosety I; Luxembourg Centre for Systems Biomedicine (LCSB), Developmental and Cellular Biology, University of Luxembourg, Belvaux L-4367, Luxembourg., Schwamborn JC; Luxembourg Centre for Systems Biomedicine (LCSB), Developmental and Cellular Biology, University of Luxembourg, Belvaux L-4367, Luxembourg., Sardi SP; Rare and Neurological Diseases Therapeutic Area, Sanofi, Framingham, MA 01701, USA., Moda F; Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan 20133, Italy., Corti S; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.; Department of Pathophysiology and Transplantation (DEPT), Dino Ferrari Centre, University of Milan, Milan 20122, Italy., Comi GP; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.; Department of Pathophysiology and Transplantation (DEPT), Dino Ferrari Centre, University of Milan, Milan 20122, Italy., Blandini F; Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy., Tritsch NX; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA.; Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY 10017, USA., Bortolozzi M; Department of Physics and Astronomy 'G. Galilei', University of Padua, Padua 35131, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padua 35129, Italy., Ferrero S; Division of Pathology, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan 20122, Italy.; Department of Biomedical, Surgical, and Dental Sciences, University of Milan, Milan 20122, Italy., Cribiù FM; Division of Pathology, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan 20122, Italy., Wisniewski T; Center for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, NY 10016, USA.; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA., Asselta R; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan 20072, Italy.; Medical Genetics and RNA Biology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan 20089, Italy., Aureli M; Department of Medical Biotechnology and Translational Medicine, University of Milano, Milan 20054, Italy., Bellucci A; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy., Di Fonzo A; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.
Source: Brain : a journal of neurology [Brain] 2025 Apr 03; Vol. 148 (4), pp. 1242-1257.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
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  Data: Lewy pathology formation in patient-derived GBA1 Parkinson's disease midbrain organoids.
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  Data: <searchLink fieldCode="AU" term="%22Frattini+E%22">Frattini E</searchLink>; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Faustini+G%22">Faustini G</searchLink>; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.<br /><searchLink fieldCode="AU" term="%22Lopez+G%22">Lopez G</searchLink>; Division of Pathology, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Carsana+EV%22">Carsana EV</searchLink>; Department of Medical Biotechnology and Translational Medicine, University of Milano, Milan 20054, Italy.<br /><searchLink fieldCode="AU" term="%22Tosi+M%22">Tosi M</searchLink>; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Trezzi+I%22">Trezzi I</searchLink>; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Magni+M%22">Magni M</searchLink>; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Soldà+G%22">Soldà G</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan 20072, Italy.; Medical Genetics and RNA Biology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan 20089, Italy.<br /><searchLink fieldCode="AU" term="%22Straniero+L%22">Straniero L</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan 20072, Italy.; Medical Genetics and RNA Biology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan 20089, Italy.<br /><searchLink fieldCode="AU" term="%22Facchi+D%22">Facchi D</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan 20072, Italy.; Medical Genetics and RNA Biology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan 20089, Italy.<br /><searchLink fieldCode="AU" term="%22Samarani+M%22">Samarani M</searchLink>; Unité de Trafic Membranaire et Pathogénèse, Département de Biologie Cellulaire et de l'Infection, Institut Pasteur, Paris 75015, France.<br /><searchLink fieldCode="AU" term="%22Martá-Ariza+M%22">Martá-Ariza M</searchLink>; Center for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, NY 10016, USA.; Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona 08193, Spain.<br /><searchLink fieldCode="AU" term="%22De+Luca+CMG%22">De Luca CMG</searchLink>; Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Vezzoli+E%22">Vezzoli E</searchLink>; Advanced Light and Electron Microscopy BioImaging Centre (ALEMBIC), IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.<br /><searchLink fieldCode="AU" term="%22Pittaro+A%22">Pittaro A</searchLink>; Division of Pathology, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Stepanyan+A%22">Stepanyan A</searchLink>; Unità Operativa Complessa, Chirurgia Generale 3, University Hospital of Padua, Padua 35128, Italy.<br /><searchLink fieldCode="AU" term="%22Silipigni+R%22">Silipigni R</searchLink>; Laboratory of Medical Genetics, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Rosety+I%22">Rosety I</searchLink>; Luxembourg Centre for Systems Biomedicine (LCSB), Developmental and Cellular Biology, University of Luxembourg, Belvaux L-4367, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Schwamborn+JC%22">Schwamborn JC</searchLink>; Luxembourg Centre for Systems Biomedicine (LCSB), Developmental and Cellular Biology, University of Luxembourg, Belvaux L-4367, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Sardi+SP%22">Sardi SP</searchLink>; Rare and Neurological Diseases Therapeutic Area, Sanofi, Framingham, MA 01701, USA.<br /><searchLink fieldCode="AU" term="%22Moda+F%22">Moda F</searchLink>; Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Corti+S%22">Corti S</searchLink>; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.; Department of Pathophysiology and Transplantation (DEPT), Dino Ferrari Centre, University of Milan, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Comi+GP%22">Comi GP</searchLink>; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.; Department of Pathophysiology and Transplantation (DEPT), Dino Ferrari Centre, University of Milan, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Blandini+F%22">Blandini F</searchLink>; Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Tritsch+NX%22">Tritsch NX</searchLink>; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA.; Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY 10017, USA.<br /><searchLink fieldCode="AU" term="%22Bortolozzi+M%22">Bortolozzi M</searchLink>; 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Galilei', University of Padua, Padua 35131, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padua 35129, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrero+S%22">Ferrero S</searchLink>; Division of Pathology, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan 20122, Italy.; Department of Biomedical, Surgical, and Dental Sciences, University of Milan, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Cribiù+FM%22">Cribiù FM</searchLink>; Division of Pathology, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Wisniewski+T%22">Wisniewski T</searchLink>; Center for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, NY 10016, USA.; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Asselta+R%22">Asselta R</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan 20072, Italy.; Medical Genetics and RNA Biology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan 20089, Italy.<br /><searchLink fieldCode="AU" term="%22Aureli+M%22">Aureli M</searchLink>; Department of Medical Biotechnology and Translational Medicine, University of Milano, Milan 20054, Italy.<br /><searchLink fieldCode="AU" term="%22Bellucci+A%22">Bellucci A</searchLink>; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Fonzo+A%22">Di Fonzo A</searchLink>; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.
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