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The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.

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Title: The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.
Authors: Vendeville S; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Amblard F; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 100 Woodruff Circle, Atlanta, Georgia 30322, United States., Bassit L; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 100 Woodruff Circle, Atlanta, Georgia 30322, United States., Beigelman LN; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Blatt LM; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Chen X; WuXi AppTec, 288 Fute Zhong Road Waigaoqiao Free Trade Zone, Pudong New Area, Shanghai, 200131, China., Chou L; WuXi AppTec, 288 Fute Zhong Road Waigaoqiao Free Trade Zone, Pudong New Area, Shanghai, 200131, China., Kum DB; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Chanda S; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Deval J; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Geng X; WuXi AppTec, 288 Fute Zhong Road Waigaoqiao Free Trade Zone, Pudong New Area, Shanghai, 200131, China., Gupta K; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Jekle A; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Hu H; Pharmaron Beijing Co Ltd, 6 Taihe Road, BDA, Beijing 100176, China., Hu X; Pharmaron Beijing Co Ltd, 6 Taihe Road, BDA, Beijing 100176, China., Kang H; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Liu C; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Liu J; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., McGowan DC; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Misner DL; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Raboisson P; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Sanchez AA; Novalix, Gaston Geenslaan 1, 3001 Leuven, Belgium., Serebryany V; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Stoycheva AD; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Symons JA; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Tan H; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Vanrusselt H; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Williams C; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Welch M; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Zhang L; Pharmaron Beijing Co Ltd, 6 Taihe Road, BDA, Beijing 100176, China., Zhang Q; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Zhang Y; WuXi AppTec, 288 Fute Zhong Road Waigaoqiao Free Trade Zone, Pudong New Area, Shanghai, 200131, China., Schinazi RF; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 100 Woodruff Circle, Atlanta, Georgia 30322, United States., Smith DB; Aligos Therapeutics, Inc., 1 Corporate Dr., Second Floor, South San Francisco, California 94080, United States., Debing Y; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Dec 12; Vol. 67 (23), pp. 21126-21142. Date of Electronic Publication: 2024 Nov 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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