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State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases.

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Title: State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases.
Authors: Van Linthout S; Berlin Institute of Health (BIH) at Charité - Universitätmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany.; German Center for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany., Stellos K; Department of Cardiovascular Research, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Mannheim, Germany.; Helmholtz Institute for Translational AngioCardioScience (HI-TAC), Mannheim, Germany.; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle, UK., Giacca M; School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, London, UK; Department of Medical Sciences, University of Trieste, Trieste, Italy., Bertero E; Cardiovascular Unit, Department of Internal Medicine, University of Genova, Genova, Italy., Cannata A; School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, London, UK., Carrier L; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany., Garcia-Pavia P; Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERCV, Madrid, Spain.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Universidad Francisco de Vitoria (UFV), Madrid, Spain., Ghigo A; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone,' University of Torino, Torino, Italy., González A; Program of Cardiovascular Diseases, CIMA and Department of Pathology, Anatomy and Physiology, Universidad de Navarra, Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.; CIBERCV (Network for Biomedical Research in Cardiovascular Disease), Instituto de Salud Carlos II, Madrid, Spain., Haugaa KH; ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Imazio M; Department of Medicine (DMED), University of Udine, and Cardiothoracic Department ASUFC, University Hospital Santa Maria della Misericordia, Udine, Italy., Lopes LR; Institute of Cardiovascular Science, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Most P; Department of Cardiology, Angiology, Pulmonology, University Hospital Heidelberg, Heidelberg, Germany., Pollesello P; Content and Communication, Branded Products, Espoo, Finland., Schunkert H; Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Streckfuss-Bömeke K; Clinic for Cardiology and Pneumology, University Medical Center, Göttingen, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, Göttingen, Germany.; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.; Department of Translational Research, Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Würzburg, Germany., Thum T; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany., Tocchetti CG; Department of Translational Medical Sciences; Center for Basic and Clinical Immunology Research (CISI); Interdepartmental Center for Clinical and Translational Research (CIRCET); Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy., Tschöpe C; Berlin Institute of Health (BIH) at Charité - Universitätmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany.; German Center for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany.; Deutsches Herzzentrum der Charité (DHZC), Department of Cardiology, Angiology and Intensive Medicine, Campus Virchow Klinikum, Berlin, Germany., van der Meer P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., van Rooij E; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., Metra M; Cardiology, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy., Rosano GMC; Cardiovascular Clinical Academic Group, St. George's University Hospitals, NHS Trust, University of London, London, UK.; Cardiology, San Raffaele Cassino Hospital, Cassino, Italy.; Department of Human Sciences and Promotion of Quality of Life, San Raffaele University of Rome, Rome, Italy., Heymans S; Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.; Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; European Reference Network for Rare Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.
Source: European journal of heart failure [Eur J Heart Fail] 2025 Jan; Vol. 27 (1), pp. 5-25. Date of Electronic Publication: 2024 Nov 22.
Publication Type: Journal Article; Review
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 100887595 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0844 (Electronic) Linking ISSN: 13889842 NLM ISO Abbreviation: Eur J Heart Fail Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases.
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  Data: <searchLink fieldCode="AU" term="%22Van+Linthout+S%22">Van Linthout S</searchLink>; Berlin Institute of Health (BIH) at Charité - Universitätmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany.; German Center for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Stellos+K%22">Stellos K</searchLink>; Department of Cardiovascular Research, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Mannheim, Germany.; Helmholtz Institute for Translational AngioCardioScience (HI-TAC), Mannheim, Germany.; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Giacca+M%22">Giacca M</searchLink>; School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, London, UK; Department of Medical Sciences, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Bertero+E%22">Bertero E</searchLink>; Cardiovascular Unit, Department of Internal Medicine, University of Genova, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Cannata+A%22">Cannata A</searchLink>; School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Carrier+L%22">Carrier L</searchLink>; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Garcia-Pavia+P%22">Garcia-Pavia P</searchLink>; Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERCV, Madrid, Spain.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Universidad Francisco de Vitoria (UFV), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ghigo+A%22">Ghigo A</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone,' University of Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22González+A%22">González A</searchLink>; Program of Cardiovascular Diseases, CIMA and Department of Pathology, Anatomy and Physiology, Universidad de Navarra, Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.; CIBERCV (Network for Biomedical Research in Cardiovascular Disease), Instituto de Salud Carlos II, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Haugaa+KH%22">Haugaa KH</searchLink>; ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Imazio+M%22">Imazio M</searchLink>; Department of Medicine (DMED), University of Udine, and Cardiothoracic Department ASUFC, University Hospital Santa Maria della Misericordia, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Lopes+LR%22">Lopes LR</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Most+P%22">Most P</searchLink>; Department of Cardiology, Angiology, Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pollesello+P%22">Pollesello P</searchLink>; Content and Communication, Branded Products, Espoo, Finland.<br /><searchLink fieldCode="AU" term="%22Schunkert+H%22">Schunkert H</searchLink>; Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Streckfuss-Bömeke+K%22">Streckfuss-Bömeke K</searchLink>; Clinic for Cardiology and Pneumology, University Medical Center, Göttingen, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, Göttingen, Germany.; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.; Department of Translational Research, Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Thum+T%22">Thum T</searchLink>; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Tocchetti+CG%22">Tocchetti CG</searchLink>; Department of Translational Medical Sciences; Center for Basic and Clinical Immunology Research (CISI); Interdepartmental Center for Clinical and Translational Research (CIRCET); Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Tschöpe+C%22">Tschöpe C</searchLink>; Berlin Institute of Health (BIH) at Charité - Universitätmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany.; German Center for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany.; Deutsches Herzzentrum der Charité (DHZC), Department of Cardiology, Angiology and Intensive Medicine, Campus Virchow Klinikum, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22van+der+Meer+P%22">van der Meer P</searchLink>; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Rooij+E%22">van Rooij E</searchLink>; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Metra+M%22">Metra M</searchLink>; Cardiology, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Rosano+GMC%22">Rosano GMC</searchLink>; Cardiovascular Clinical Academic Group, St. George's University Hospitals, NHS Trust, University of London, London, UK.; Cardiology, San Raffaele Cassino Hospital, Cassino, Italy.; Department of Human Sciences and Promotion of Quality of Life, San Raffaele University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Heymans+S%22">Heymans S</searchLink>; Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.; Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; European Reference Network for Rare Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.
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