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The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging.

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Title: The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging.
Authors: Zhou C; The First Affiliated Hospital of Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Institute for Advanced Study, Synthetic Biology Research Center, International Cancer Center of Shenzhen University, Shenzhen, 518039, China.; BGI Research, Changzhou, 213299, China.; Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.; China College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Wang Y; BGI Research, Changzhou, 213299, China.; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, 518083, China., Huang Y; The First Affiliated Hospital of Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Institute for Advanced Study, Synthetic Biology Research Center, International Cancer Center of Shenzhen University, Shenzhen, 518039, China., An Y; Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing, China., Fu X; BGI Research, Changzhou, 213299, China.; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, 518083, China., Yang D; Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing, China., Wang Y; The First Affiliated Hospital of Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Institute for Advanced Study, Synthetic Biology Research Center, International Cancer Center of Shenzhen University, Shenzhen, 518039, China., Zhang J; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, 518083, China., Mitchell LA; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, 10016, USA.; Neochromosome, Inc., Long Island City, NY, USA., Bader JS; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Cai Y; Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK., Dai J; Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.; China College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China., Boeke JD; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, 10016, USA.; Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, NY, 11201, USA., Cai Z; The First Affiliated Hospital of Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Institute for Advanced Study, Synthetic Biology Research Center, International Cancer Center of Shenzhen University, Shenzhen, 518039, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China., Xie Z; Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing, China. xiezhengwei@hsc.pku.edu.cn., Shen Y; BGI Research, Changzhou, 213299, China. shenyue@genomics.cn.; China College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China. shenyue@genomics.cn.; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, 518083, China. shenyue@genomics.cn., Huang W; The First Affiliated Hospital of Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Institute for Advanced Study, Synthetic Biology Research Center, International Cancer Center of Shenzhen University, Shenzhen, 518039, China. wr.huang@siat.ac.cn.; Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. wr.huang@siat.ac.cn.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China. wr.huang@siat.ac.cn.; Guangdong Engineering Technology Research Center for clinical application of cancer genome, Guangdong, China. wr.huang@siat.ac.cn.
Source: Nature communications [Nat Commun] 2024 Nov 22; Vol. 15 (1), pp. 10139. Date of Electronic Publication: 2024 Nov 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+C%22">Zhou C</searchLink>; The First Affiliated Hospital of Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Institute for Advanced Study, Synthetic Biology Research Center, International Cancer Center of Shenzhen University, Shenzhen, 518039, China.; BGI Research, Changzhou, 213299, China.; Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.; China College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; BGI Research, Changzhou, 213299, China.; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, 518083, China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; The First Affiliated Hospital of Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Institute for Advanced Study, Synthetic Biology Research Center, International Cancer Center of Shenzhen University, Shenzhen, 518039, China.<br /><searchLink fieldCode="AU" term="%22An+Y%22">An Y</searchLink>; Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; BGI Research, Changzhou, 213299, China.; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, 518083, China.<br /><searchLink fieldCode="AU" term="%22Yang+D%22">Yang D</searchLink>; Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; The First Affiliated Hospital of Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Institute for Advanced Study, Synthetic Biology Research Center, International Cancer Center of Shenzhen University, Shenzhen, 518039, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, 518083, China.<br /><searchLink fieldCode="AU" term="%22Mitchell+LA%22">Mitchell LA</searchLink>; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, 10016, USA.; Neochromosome, Inc., Long Island City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bader+JS%22">Bader JS</searchLink>; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.<br /><searchLink fieldCode="AU" term="%22Dai+J%22">Dai J</searchLink>; Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.; China College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Boeke+JD%22">Boeke JD</searchLink>; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, 10016, USA.; Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, NY, 11201, USA.<br /><searchLink fieldCode="AU" term="%22Cai+Z%22">Cai Z</searchLink>; The First Affiliated Hospital of Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Institute for Advanced Study, Synthetic Biology Research Center, International Cancer Center of Shenzhen University, Shenzhen, 518039, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.<br /><searchLink fieldCode="AU" term="%22Xie+Z%22">Xie Z</searchLink>; Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing, China. xiezhengwei@hsc.pku.edu.cn.<br /><searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; BGI Research, Changzhou, 213299, China. shenyue@genomics.cn.; China College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China. shenyue@genomics.cn.; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, 518083, China. shenyue@genomics.cn.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; The First Affiliated Hospital of Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Institute for Advanced Study, Synthetic Biology Research Center, International Cancer Center of Shenzhen University, Shenzhen, 518039, China. wr.huang@siat.ac.cn.; Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. wr.huang@siat.ac.cn.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China. wr.huang@siat.ac.cn.; Guangdong Engineering Technology Research Center for clinical application of cancer genome, Guangdong, China. wr.huang@siat.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2024 Nov 22; Vol. 15 (1), pp. 10139. <i>Date of Electronic Publication: </i>2024 Nov 22.
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