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First-in-Human Phase I Trial to Assess the Safety and Immunogenicity of an Orf Virus-Based COVID-19 Vaccine Booster.

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Title: First-in-Human Phase I Trial to Assess the Safety and Immunogenicity of an Orf Virus-Based COVID-19 Vaccine Booster.
Authors: Esen M; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Centre de Recherches Médicales de Lambaréné, Lambaréné BP 242, Gabon.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany., Fischer-Herr J; Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Bernhard Nocht Center for Clinical Trials (BNCCT), 20359 Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Sites Hamburg-Lübeck-Borstel-Riems, Germany., Gabor JJ; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Klinikverbund-Suedwest, Germany., Gaile JM; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Klinikverbund-Suedwest, Germany., Fleischmann WA; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Center for Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Smeenk GW; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; MediTÜV GmbH & Co. KG, Hannover, Standort Hagen, 44263 Dortmund, Germany., de Moraes RA; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany., Bélard S; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany., Calle CL; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany., Woldearegai TG; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany., Egger-Adam D; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany., Haug V; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Institute of Immunology, University Hospital Tübingen, 72076 Tübingen, Germany., Metz C; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Institute of Immunology, University Hospital Tübingen, 72076 Tübingen, Germany., Reguzova A; Institute of Immunology, University Hospital Tübingen, 72076 Tübingen, Germany., Löffler MW; Institute of Immunology, University Hospital Tübingen, 72076 Tübingen, Germany.; Institute for Clinical and Experimental Transfusion Medicine, Medical Faculty, University Hospital Tübingen, 72076 Tübingen, Germany., Balode B; Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Bernhard Nocht Center for Clinical Trials (BNCCT), 20359 Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Sites Hamburg-Lübeck-Borstel-Riems, Germany., Matthies LC; Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Bernhard Nocht Center for Clinical Trials (BNCCT), 20359 Hamburg, Germany., Ramharter M; Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Bernhard Nocht Center for Clinical Trials (BNCCT), 20359 Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Sites Hamburg-Lübeck-Borstel-Riems, Germany., Amann R; Institute of Immunology, University Hospital Tübingen, 72076 Tübingen, Germany., Kremsner PG; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Centre de Recherches Médicales de Lambaréné, Lambaréné BP 242, Gabon.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany.
Source: Vaccines [Vaccines (Basel)] 2024 Nov 18; Vol. 12 (11). Date of Electronic Publication: 2024 Nov 18.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: First-in-Human Phase I Trial to Assess the Safety and Immunogenicity of an Orf Virus-Based COVID-19 Vaccine Booster.
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  Data: <searchLink fieldCode="AU" term="%22Esen+M%22">Esen M</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Centre de Recherches Médicales de Lambaréné, Lambaréné BP 242, Gabon.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer-Herr+J%22">Fischer-Herr J</searchLink>; Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Bernhard Nocht Center for Clinical Trials (BNCCT), 20359 Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Sites Hamburg-Lübeck-Borstel-Riems, Germany.<br /><searchLink fieldCode="AU" term="%22Gabor+JJ%22">Gabor JJ</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Klinikverbund-Suedwest, Germany.<br /><searchLink fieldCode="AU" term="%22Gaile+JM%22">Gaile JM</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Klinikverbund-Suedwest, Germany.<br /><searchLink fieldCode="AU" term="%22Fleischmann+WA%22">Fleischmann WA</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Center for Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Smeenk+GW%22">Smeenk GW</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; MediTÜV GmbH & Co. KG, Hannover, Standort Hagen, 44263 Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22de+Moraes+RA%22">de Moraes RA</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Bélard+S%22">Bélard S</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Calle+CL%22">Calle CL</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Woldearegai+TG%22">Woldearegai TG</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Egger-Adam+D%22">Egger-Adam D</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Haug+V%22">Haug V</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Institute of Immunology, University Hospital Tübingen, 72076 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Metz+C%22">Metz C</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Institute of Immunology, University Hospital Tübingen, 72076 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Reguzova+A%22">Reguzova A</searchLink>; Institute of Immunology, University Hospital Tübingen, 72076 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Löffler+MW%22">Löffler MW</searchLink>; Institute of Immunology, University Hospital Tübingen, 72076 Tübingen, Germany.; Institute for Clinical and Experimental Transfusion Medicine, Medical Faculty, University Hospital Tübingen, 72076 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Balode+B%22">Balode B</searchLink>; Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Bernhard Nocht Center for Clinical Trials (BNCCT), 20359 Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Sites Hamburg-Lübeck-Borstel-Riems, Germany.<br /><searchLink fieldCode="AU" term="%22Matthies+LC%22">Matthies LC</searchLink>; Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Bernhard Nocht Center for Clinical Trials (BNCCT), 20359 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ramharter+M%22">Ramharter M</searchLink>; Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Bernhard Nocht Center for Clinical Trials (BNCCT), 20359 Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Sites Hamburg-Lübeck-Borstel-Riems, Germany.<br /><searchLink fieldCode="AU" term="%22Amann+R%22">Amann R</searchLink>; Institute of Immunology, University Hospital Tübingen, 72076 Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kremsner+PG%22">Kremsner PG</searchLink>; Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany.; Centre de Recherches Médicales de Lambaréné, Lambaréné BP 242, Gabon.; German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101629355%22">Vaccines</searchLink> [Vaccines (Basel)] 2024 Nov 18; Vol. 12 (11). <i>Date of Electronic Publication: </i>2024 Nov 18.
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