Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline.

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Title: Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline.
Authors: Chen Y; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore., Torta F; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore.; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore., Koh HWL; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Benke PI; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore., Gurung RL; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Liu JJ; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Ang K; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Shao YM; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Chan GC; Division of Nephrology, Department of Medicine, National University Hospital, Singapore, Republic of Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Republic of Singapore., Choo JC; Department of Renal Medicine, Singapore General Hospital, Singapore, Republic of Singapore., Ching J; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Republic of Singapore.; KK Research Centre, KK Women's and Children's Hospital, Singapore, Republic of Singapore., Kovalik JP; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Republic of Singapore., Kalhan T; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore., Dorajoo R; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Khor CC; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Li Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.; Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA., Tang WE; National Healthcare Group Polyclinics, Singapore, Republic of Singapore., Seah DEJ; National Healthcare Group Polyclinics, Singapore, Republic of Singapore., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Republic of Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Republic of Singapore., Sobota RM; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Venkataraman K; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore., Coffman T; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Republic of Singapore., Wenk MR; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore. ephsx@nus.edu.sg., Lim SC; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore. lim.su.chi@ktph.com.sg.; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore. lim.su.chi@ktph.com.sg.; Diabetes Center, Khoo Teck Puat Hospital, Singapore, Republic of Singapore. lim.su.chi@ktph.com.sg.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore. lim.su.chi@ktph.com.sg., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore. mdctes@nus.edu.sg.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Republic of Singapore. mdctes@nus.edu.sg.
Source: Diabetologia [Diabetologia] 2025 Mar; Vol. 68 (3), pp. 557-575. Date of Electronic Publication: 2024 Dec 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
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  Data: Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Torta+F%22">Torta F</searchLink>; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore.; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Koh+HWL%22">Koh HWL</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Benke+PI%22">Benke PI</searchLink>; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Gurung+RL%22">Gurung RL</searchLink>; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Liu+JJ%22">Liu JJ</searchLink>; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Ang+K%22">Ang K</searchLink>; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Shao+YM%22">Shao YM</searchLink>; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+GC%22">Chan GC</searchLink>; Division of Nephrology, Department of Medicine, National University Hospital, Singapore, Republic of Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Choo+JC%22">Choo JC</searchLink>; Department of Renal Medicine, Singapore General Hospital, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Ching+J%22">Ching J</searchLink>; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Republic of Singapore.; KK Research Centre, KK Women's and Children's Hospital, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Kovalik+JP%22">Kovalik JP</searchLink>; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Kalhan+T%22">Kalhan T</searchLink>; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Dorajoo+R%22">Dorajoo R</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Khor+CC%22">Khor CC</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.; Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Tang+WE%22">Tang WE</searchLink>; National Healthcare Group Polyclinics, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Seah+DEJ%22">Seah DEJ</searchLink>; National Healthcare Group Polyclinics, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Sabanayagam+C%22">Sabanayagam C</searchLink>; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Republic of Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Sobota+RM%22">Sobota RM</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Venkataraman+K%22">Venkataraman K</searchLink>; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Coffman+T%22">Coffman T</searchLink>; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Wenk+MR%22">Wenk MR</searchLink>; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Sim+X%22">Sim X</searchLink>; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore. ephsx@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Lim+SC%22">Lim SC</searchLink>; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore. lim.su.chi@ktph.com.sg.; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore. lim.su.chi@ktph.com.sg.; Diabetes Center, Khoo Teck Puat Hospital, Singapore, Republic of Singapore. lim.su.chi@ktph.com.sg.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore. lim.su.chi@ktph.com.sg.<br /><searchLink fieldCode="AU" term="%22Tai+ES%22">Tai ES</searchLink>; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore. mdctes@nus.edu.sg.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Republic of Singapore. mdctes@nus.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2025 Mar; Vol. 68 (3), pp. 557-575. <i>Date of Electronic Publication: </i>2024 Dec 02.
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