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Defining within-host SARS-CoV-2 RNA viral load kinetics during acute COVID-19 infection within different respiratory compartments and their respective associations with host infectiousness: a protocol for a systematic review and meta-analysis.

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Title: Defining within-host SARS-CoV-2 RNA viral load kinetics during acute COVID-19 infection within different respiratory compartments and their respective associations with host infectiousness: a protocol for a systematic review and meta-analysis.
Authors: Pan D; Development Centre for Population Health, University of Leicester, Leicester, UK.; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK.; Oxford Big Data Institute, University of Oxford, Oxford, UK.; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, Hong Kong School of Public Health, Hong Kong, Hong Kong., Martin CA; Development Centre for Population Health, University of Leicester, Leicester, UK.; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK., Nazareth J; Development Centre for Population Health, University of Leicester, Leicester, UK.; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK., Sze S; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Al-Oraibi A; Development Centre for Population Health, University of Leicester, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Lifespan and Population Health, University of Nottingham, Nottingham, UK., Gogoi M; Development Centre for Population Health, University of Leicester, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK., Grolmusova N; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK., Divall P; Education Centre Library, University Hospitals of Leicester NHS Trust, Leicester, UK., Decker J; Department of Respiratory Sciences, University of Leicester, Leicester, UK., Fletcher E; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK., Williams C; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK.; Department of Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, UK., Hay J; Oxford Big Data Institute, University of Oxford, Oxford, UK., Baggaley RF; Development Centre for Population Health, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK., Wyllie AL; Department of Epidemiology of Microbial Diseases, Yale University, New Haven, Connecticut, USA., Stephenson I; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK., Gaillard E; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK.; Department of Paediatric Respiratory Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK., Nellums LB; College of Population Health, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Clark TW; Clinical and Experimental Sciences, University of Southampton, Southampton, UK.; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; NIHR Southampton Biomedical Research Centre, Southampton, UK., Van-Tam JN; Lifespan and Population Health, University of Nottingham, Nottingham, UK., Cowling BJ; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, Hong Kong School of Public Health, Hong Kong, Hong Kong.; Laboratory of Data Discovery for Health Limited, Hong Kong Science and Technology Parks Corporation, Hong Kong, Hong Kong., Hollingsworth TD; Oxford Big Data Institute, University of Oxford, Oxford, UK.; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Gray L; Leicester NIHR Biomedical Research Centre, Leicester, UK.; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Applied Research Collaborative East Midlands, Leicester, UK., Barer M; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK.; Department of Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, UK., Pareek M; Development Centre for Population Health, University of Leicester, Leicester, UK manish.pareek@leicester.ac.uk.; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK.; NIHR Applied Research Collaborative East Midlands, Leicester, UK.
Source: BMJ open [BMJ Open] 2024 Dec 02; Vol. 14 (12), pp. e085127. Date of Electronic Publication: 2024 Dec 02.
Publication Type: Journal Article
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  Data: <searchLink fieldCode="AU" term="%22Pan+D%22">Pan D</searchLink>; Development Centre for Population Health, University of Leicester, Leicester, UK.; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK.; Oxford Big Data Institute, University of Oxford, Oxford, UK.; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, Hong Kong School of Public Health, Hong Kong, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Martin+CA%22">Martin CA</searchLink>; Development Centre for Population Health, University of Leicester, Leicester, UK.; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Nazareth+J%22">Nazareth J</searchLink>; Development Centre for Population Health, University of Leicester, Leicester, UK.; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Sze+S%22">Sze S</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Al-Oraibi+A%22">Al-Oraibi A</searchLink>; Development Centre for Population Health, University of Leicester, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Lifespan and Population Health, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Gogoi+M%22">Gogoi M</searchLink>; Development Centre for Population Health, University of Leicester, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Grolmusova+N%22">Grolmusova N</searchLink>; 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College of Population Health, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.<br /><searchLink fieldCode="AU" term="%22Clark+TW%22">Clark TW</searchLink>; Clinical and Experimental Sciences, University of Southampton, Southampton, UK.; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; NIHR Southampton Biomedical Research Centre, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Van-Tam+JN%22">Van-Tam JN</searchLink>; Lifespan and Population Health, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Cowling+BJ%22">Cowling BJ</searchLink>; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, Hong Kong School of Public Health, Hong Kong, Hong Kong.; Laboratory of Data Discovery for Health Limited, Hong Kong Science and Technology Parks Corporation, Hong Kong, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Hollingsworth+TD%22">Hollingsworth TD</searchLink>; 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Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Biomedical Research Centre, Leicester, UK.; NIHR Applied Research Collaborative East Midlands, Leicester, UK.
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