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Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.

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Bibliographic Details
Title: Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.
Authors: Lederberg OL; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Yan NL; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Sanchez J; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Ren W; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Ash C; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Wilkens SJ; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Qiu H; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Qin B; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Grant VH; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Jackman AB; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Stanfield RL; Department of Integrative Structural and Computational Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States., Wilson IA; Department of Integrative Structural and Computational Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road., La Jolla, California 92037, United States., Petrassi HM; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Rhoades D; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Kelly JW; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road., La Jolla, California 92037, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Dec 12; Vol. 67 (23), pp. 21070-21105. Date of Electronic Publication: 2024 Dec 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.4c01773