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Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.

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Title: Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.
Authors: Lederberg OL; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Yan NL; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Sanchez J; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Ren W; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Ash C; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Wilkens SJ; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Qiu H; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Qin B; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Grant VH; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Jackman AB; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Stanfield RL; Department of Integrative Structural and Computational Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States., Wilson IA; Department of Integrative Structural and Computational Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road., La Jolla, California 92037, United States., Petrassi HM; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States., Rhoades D; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Kelly JW; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road., La Jolla, California 92037, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Dec 12; Vol. 67 (23), pp. 21070-21105. Date of Electronic Publication: 2024 Dec 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.
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  Data: <searchLink fieldCode="AU" term="%22Lederberg+OL%22">Lederberg OL</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Yan+NL%22">Yan NL</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Sanchez+J%22">Sanchez J</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Ren+W%22">Ren W</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Ash+C%22">Ash C</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Wilkens+SJ%22">Wilkens SJ</searchLink>; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Qiu+H%22">Qiu H</searchLink>; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Qin+B%22">Qin B</searchLink>; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Grant+VH%22">Grant VH</searchLink>; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Jackman+AB%22">Jackman AB</searchLink>; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Stanfield+RL%22">Stanfield RL</searchLink>; Department of Integrative Structural and Computational Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Wilson+IA%22">Wilson IA</searchLink>; Department of Integrative Structural and Computational Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road., La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Petrassi+HM%22">Petrassi HM</searchLink>; Protego Biopharma, 10945 Vista Sorrento Parkway, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Rhoades+D%22">Rhoades D</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+JW%22">Kelly JW</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road., La Jolla, California 92037, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Dec 12; Vol. 67 (23), pp. 21070-21105. <i>Date of Electronic Publication: </i>2024 Dec 03.
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        Value: 10.1021/acs.jmedchem.4c01773
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              Text: 2024 Dec 12
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