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The sodium/glucose cotransporter 2 inhibitor Empagliflozin inhibits long QT 3 late sodium currents in a mutation specific manner.

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Title: The sodium/glucose cotransporter 2 inhibitor Empagliflozin inhibits long QT 3 late sodium currents in a mutation specific manner.
Authors: Lunsonga LC; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada., Fatehi M; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada., Long W; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada., Barr AJ; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada., Gruber B; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada., Chattopadhyay A; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton. 2-35 Medical Sciences Building, Edmonton T6G 2H1, Alberta, Canada., Barakat K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton. 2-35 Medical Sciences Building, Edmonton T6G 2H1, Alberta, Canada., Edwards AG; Department of Computational Physiology, Simula Research Laboratory, Kristian Augusts gate 23, Oslo 0164, Norway., Light PE; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada. Electronic address: plight@ualberta.ca.
Source: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2025 Jan; Vol. 198, pp. 99-111. Date of Electronic Publication: 2024 Dec 02.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 0262322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8584 (Electronic) Linking ISSN: 00222828 NLM ISO Abbreviation: J Mol Cell Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The sodium/glucose cotransporter 2 inhibitor Empagliflozin inhibits long QT 3 late sodium currents in a mutation specific manner.
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  Data: <searchLink fieldCode="AU" term="%22Lunsonga+LC%22">Lunsonga LC</searchLink>; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Fatehi+M%22">Fatehi M</searchLink>; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Long+W%22">Long W</searchLink>; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Barr+AJ%22">Barr AJ</searchLink>; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Gruber+B%22">Gruber B</searchLink>; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Chattopadhyay+A%22">Chattopadhyay A</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton. 2-35 Medical Sciences Building, Edmonton T6G 2H1, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Barakat+K%22">Barakat K</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton. 2-35 Medical Sciences Building, Edmonton T6G 2H1, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Edwards+AG%22">Edwards AG</searchLink>; Department of Computational Physiology, Simula Research Laboratory, Kristian Augusts gate 23, Oslo 0164, Norway.<br /><searchLink fieldCode="AU" term="%22Light+PE%22">Light PE</searchLink>; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada. Electronic address: plight@ualberta.ca.
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  Data: <searchLink fieldCode="JN" term="%220262322%22">Journal of molecular and cellular cardiology</searchLink> [J Mol Cell Cardiol] 2025 Jan; Vol. 198, pp. 99-111. <i>Date of Electronic Publication: </i>2024 Dec 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0262322 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-8584 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222828%22">00222828 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Cell Cardiol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.yjmcc.2024.11.014
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      – Code: eng
        Text: English
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              Text: 2025 Jan
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