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CDK9 recruits HUWE1 to degrade RARα and offers therapeutic opportunities for cutaneous T-cell lymphoma.

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Title: CDK9 recruits HUWE1 to degrade RARα and offers therapeutic opportunities for cutaneous T-cell lymphoma.
Authors: Luo CH; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Hu LH; Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Liu JY; Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Xia L; Department of Core Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhou L; Department of Core Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Sun RH; Gluetacs Therapeutics (Shanghai) Co., Ltd., Shanghai, China., Lin CC; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China., Qiu X; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China., Jiang B; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China., Yang MY; Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ymy@shsmu.edu.cn., Zhang XH; Center of Genome and Personalized Medicine, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. zhangxuehong1984@163.com., Yang XB; Gluetacs Therapeutics (Shanghai) Co., Ltd., Shanghai, China. yang.xiaobao@gluetacs.com., Chen GQ; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. chengq@shsmu.edu.cn.; Institute of Aging & Tissue Regeneration, State Key Laboratory of Systems Medicine for Cancer, Research Units of Stress and Tumor (2019RU043), Chinese Academy of Medical Sciences, Ren-Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. chengq@shsmu.edu.cn.; School of Basic Medicine and Life Science, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China. chengq@shsmu.edu.cn., Lu Y; Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. stove@shsmu.edu.cn.
Source: Nature communications [Nat Commun] 2024 Dec 05; Vol. 15 (1), pp. 10594. Date of Electronic Publication: 2024 Dec 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CDK9 recruits HUWE1 to degrade RARα and offers therapeutic opportunities for cutaneous T-cell lymphoma.
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  Data: <searchLink fieldCode="AU" term="%22Luo+CH%22">Luo CH</searchLink>; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Hu+LH%22">Hu LH</searchLink>; Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+JY%22">Liu JY</searchLink>; Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xia+L%22">Xia L</searchLink>; Department of Core Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Department of Core Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Sun+RH%22">Sun RH</searchLink>; Gluetacs Therapeutics (Shanghai) Co., Ltd., Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lin+CC%22">Lin CC</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Qiu+X%22">Qiu X</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Jiang+B%22">Jiang B</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yang+MY%22">Yang MY</searchLink>; Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ymy@shsmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+XH%22">Zhang XH</searchLink>; Center of Genome and Personalized Medicine, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. zhangxuehong1984@163.com.<br /><searchLink fieldCode="AU" term="%22Yang+XB%22">Yang XB</searchLink>; Gluetacs Therapeutics (Shanghai) Co., Ltd., Shanghai, China. yang.xiaobao@gluetacs.com.<br /><searchLink fieldCode="AU" term="%22Chen+GQ%22">Chen GQ</searchLink>; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. chengq@shsmu.edu.cn.; Institute of Aging & Tissue Regeneration, State Key Laboratory of Systems Medicine for Cancer, Research Units of Stress and Tumor (2019RU043), Chinese Academy of Medical Sciences, Ren-Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. chengq@shsmu.edu.cn.; School of Basic Medicine and Life Science, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China. chengq@shsmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. stove@shsmu.edu.cn.
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              Text: 2024 Dec 05
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