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Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors.

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Bibliographic Details
Title: Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors.
Authors: Eadsforth TC; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Torrie LS; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Rowland P; GSK, Medicines Research Centre, Stevenage, UK., Edgar EV; GSK, Medicines Research Centre, Stevenage, UK., MacLean LM; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Paterson C; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Robinson DA; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Shepherd SM; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Thomas J; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Thomas MG; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Gray DW; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Postis VLG; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., De Rycker M; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK. Electronic address: m.derycker@dundee.ac.uk.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Jan; Vol. 301 (1), pp. 108049. Date of Electronic Publication: 2024 Dec 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1083-351X
DOI:10.1016/j.jbc.2024.108049