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Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors.

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Title: Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors.
Authors: Eadsforth TC; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Torrie LS; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Rowland P; GSK, Medicines Research Centre, Stevenage, UK., Edgar EV; GSK, Medicines Research Centre, Stevenage, UK., MacLean LM; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Paterson C; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Robinson DA; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Shepherd SM; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Thomas J; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Thomas MG; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Gray DW; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Postis VLG; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., De Rycker M; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK. Electronic address: m.derycker@dundee.ac.uk.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Jan; Vol. 301 (1), pp. 108049. Date of Electronic Publication: 2024 Dec 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Eadsforth+TC%22">Eadsforth TC</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Torrie+LS%22">Torrie LS</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Rowland+P%22">Rowland P</searchLink>; GSK, Medicines Research Centre, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Edgar+EV%22">Edgar EV</searchLink>; GSK, Medicines Research Centre, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22MacLean+LM%22">MacLean LM</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Paterson+C%22">Paterson C</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+DA%22">Robinson DA</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Shepherd+SM%22">Shepherd SM</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Thomas+J%22">Thomas J</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Thomas+MG%22">Thomas MG</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Gray+DW%22">Gray DW</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Postis+VLG%22">Postis VLG</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22De+Rycker+M%22">De Rycker M</searchLink>; Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK. Electronic address: m.derycker@dundee.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Jan; Vol. 301 (1), pp. 108049. <i>Date of Electronic Publication: </i>2024 Dec 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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