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Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.

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Title: Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.
Authors: Gomez-Gonzalez PJ; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Gupta A; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Drought LG; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Patel A; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Okombo J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., van der Watt M; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa., Walker-Gray R; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Schindler KA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Burkhard AY; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Narwal SK; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Bloxham TS; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Flueck C; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Walker EM; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Rey JA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Fairhurst KJ; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Reader J; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.; Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa., Park H; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Pollard HG; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Stewart LB; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Brandner-Garrod L; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Kristan M; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Sterk GJ; Vrije Universiteit Amsterdam, Amsterdam, Netherlands., van Nuland YM; TropIQ Health Sciences, Nijmegen, Netherlands., Manko E; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., van Schalkwyk DA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Zheng Y; Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Leurs R; Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Dechering KJ; TropIQ Health Sciences, Nijmegen, Netherlands., Aguiar ACC; Federal University of São Paulo, São Paulo, Brazil., Guido RVC; Sao Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil., Pereira DB; Research Center for Tropical Medicine of Rondonia, Porto Velho, Brazil., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Nosbya SL; Infectious Diseases Research Collaboration, Kampala, Uganda., Rosenthal PJ; University of California, San Francisco, CA, USA., Cooper RA; Dominican University of California, San Rafael, CA, USA., Palmer M; Salvensis, Sandwich, UK., Parkinson T; Salvensis, Sandwich, UK., Burrows JN; Medicines for Malaria Venture, Geneva, Switzerland.; Liverpool School of Tropical Medicine, Liverpool, UK., Uhlemann AC; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Birkholtz LM; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.; Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa., Small-Saunders JL; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Duffy J; Medicines for Malaria Venture, Geneva, Switzerland., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Brown A; Salvensis, Sandwich, UK., Gardner M; Salvensis, Sandwich, UK., Baker DA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Source: Science advances [Sci Adv] 2024 Dec 06; Vol. 10 (49), pp. eadq1383. Date of Electronic Publication: 2024 Dec 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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