Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

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Title: Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.
Authors: Valerie NCK; Science for Life Laboratory, Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-141 52, Sweden. nicholas.valerie@ki.se., Sanjiv K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Mortusewicz O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Zhang SM; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Alam S; Science for Life Laboratory, Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-141 52, Sweden., Pires MJ; Science for Life Laboratory, Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-141 52, Sweden., Stigsdotter H; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Rasti A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Langelier MF; Département de Biochimie and Médecine Moléculaire, Faculté de Médecine, Université de Montréal, Montréal, QC, H3C 3J7, Canada., Rehling D; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-106 91, Sweden., Throup A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Purewal-Sidhu O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Desroses M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Onireti J; Science for Life Laboratory, Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-141 52, Sweden., Wakchaure P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Almlöf I; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Boström J; Science for Life Laboratory, Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-141 52, Sweden., Bevc L; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Benzi G; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-106 91, Sweden., Pascal JM; Département de Biochimie and Médecine Moléculaire, Faculté de Médecine, Université de Montréal, Montréal, QC, H3C 3J7, Canada., Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden., Page BDG; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, SE-171 65, Sweden.; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, V6T 1Z3, Canada., Altun M; Science for Life Laboratory, Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-141 52, Sweden.
Source: Nature communications [Nat Commun] 2024 Dec 06; Vol. 15 (1), pp. 10347. Date of Electronic Publication: 2024 Dec 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-024-54415-7