Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy.

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Title: Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy.
Authors: Ediriweera GR; Centre for Advanced Imaging and Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia., Sivaram AJ; Centre for Advanced Imaging and Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia., Cowin G; Centre for Advanced Imaging and Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia; National Imaging Facility, Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD 4072, Australia., Brown ML; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia., McAlary L; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia., Lum JS; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia; School of Medical, Indigenous and Health Sciences, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia., Fletcher NL; Centre for Advanced Imaging and Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia., Robinson L; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia., Simpson JD; Louvain Institute of Biomolecular Science and Technology, Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium., Chen L; Queensland Brain Institute (QBI), The University of Queensland, Brisbane, QLD 4072, Australia., Wasielewska JM; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia., Byrne E; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia., Finnie JW; Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, SA 5000, Australia., Manavis J; Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, SA 5000, Australia., White AR; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia., Yerbury JJ; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia., Thurecht KJ; Centre for Advanced Imaging and Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia., Vine KL; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia. Electronic address: kara@uow.edu.au.
Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Feb 10; Vol. 378, pp. 221-235. Date of Electronic Publication: 2024 Dec 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE
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  Data: Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy.
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  Data: <searchLink fieldCode="AU" term="%22Ediriweera+GR%22">Ediriweera GR</searchLink>; Centre for Advanced Imaging and Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Sivaram+AJ%22">Sivaram AJ</searchLink>; Centre for Advanced Imaging and Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Cowin+G%22">Cowin G</searchLink>; Centre for Advanced Imaging and Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia; National Imaging Facility, Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Brown+ML%22">Brown ML</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.<br /><searchLink fieldCode="AU" term="%22McAlary+L%22">McAlary L</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.<br /><searchLink fieldCode="AU" term="%22Lum+JS%22">Lum JS</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia; School of Medical, Indigenous and Health Sciences, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.<br /><searchLink fieldCode="AU" term="%22Fletcher+NL%22">Fletcher NL</searchLink>; Centre for Advanced Imaging and Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Robinson+L%22">Robinson L</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.<br /><searchLink fieldCode="AU" term="%22Simpson+JD%22">Simpson JD</searchLink>; Louvain Institute of Biomolecular Science and Technology, Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Queensland Brain Institute (QBI), The University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Wasielewska+JM%22">Wasielewska JM</searchLink>; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Byrne+E%22">Byrne E</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.<br /><searchLink fieldCode="AU" term="%22Finnie+JW%22">Finnie JW</searchLink>; Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, SA 5000, Australia.<br /><searchLink fieldCode="AU" term="%22Manavis+J%22">Manavis J</searchLink>; Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, SA 5000, Australia.<br /><searchLink fieldCode="AU" term="%22White+AR%22">White AR</searchLink>; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Yerbury+JJ%22">Yerbury JJ</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.<br /><searchLink fieldCode="AU" term="%22Thurecht+KJ%22">Thurecht KJ</searchLink>; Centre for Advanced Imaging and Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Vine+KL%22">Vine KL</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia. Electronic address: kara@uow.edu.au.
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  Data: <searchLink fieldCode="JN" term="%228607908%22">Journal of controlled release : official journal of the Controlled Release Society</searchLink> [J Control Release] 2025 Feb 10; Vol. 378, pp. 221-235. <i>Date of Electronic Publication: </i>2024 Dec 13.
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        Value: 10.1016/j.jconrel.2024.11.074
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