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Static Versus Dynamic Model Predictions of Competitive Inhibitory Metabolic Drug-Drug Interactions via Cytochromes P450: One Step Forward and Two Steps Backwards.

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Title: Static Versus Dynamic Model Predictions of Competitive Inhibitory Metabolic Drug-Drug Interactions via Cytochromes P450: One Step Forward and Two Steps Backwards.
Authors: Tiryannik I; Certara Predictive Technologies (CPT), Sheffield, UK. ivan.tiryannik@certara.com.; Centre for Applied Pharmacokinetic Research (CAPKR), The University of Manchester, Manchester, UK. ivan.tiryannik@certara.com., Heikkinen AT; Certara Predictive Technologies (CPT), Sheffield, UK., Gardner I; Certara Predictive Technologies (CPT), Sheffield, UK., Onasanwo A; Certara Predictive Technologies (CPT), Sheffield, UK., Jamei M; Certara Predictive Technologies (CPT), Sheffield, UK., Polasek TM; Centre for Medicine Use and Safety, Monash University, Melbourne, Australia.; CMAX Clinical Research Pty Ltd, Adelaide, Australia., Rostami-Hodjegan A; Certara Predictive Technologies (CPT), Sheffield, UK.; Centre for Applied Pharmacokinetic Research (CAPKR), The University of Manchester, Manchester, UK.
Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2025 Jan; Vol. 64 (1), pp. 155-170. Date of Electronic Publication: 2024 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Static Versus Dynamic Model Predictions of Competitive Inhibitory Metabolic Drug-Drug Interactions via Cytochromes P450: One Step Forward and Two Steps Backwards.
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  Data: <searchLink fieldCode="AU" term="%22Tiryannik+I%22">Tiryannik I</searchLink>; Certara Predictive Technologies (CPT), Sheffield, UK. ivan.tiryannik@certara.com.; Centre for Applied Pharmacokinetic Research (CAPKR), The University of Manchester, Manchester, UK. ivan.tiryannik@certara.com.<br /><searchLink fieldCode="AU" term="%22Heikkinen+AT%22">Heikkinen AT</searchLink>; Certara Predictive Technologies (CPT), Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Gardner+I%22">Gardner I</searchLink>; Certara Predictive Technologies (CPT), Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Onasanwo+A%22">Onasanwo A</searchLink>; Certara Predictive Technologies (CPT), Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Jamei+M%22">Jamei M</searchLink>; Certara Predictive Technologies (CPT), Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Polasek+TM%22">Polasek TM</searchLink>; Centre for Medicine Use and Safety, Monash University, Melbourne, Australia.; CMAX Clinical Research Pty Ltd, Adelaide, Australia.<br /><searchLink fieldCode="AU" term="%22Rostami-Hodjegan+A%22">Rostami-Hodjegan A</searchLink>; Certara Predictive Technologies (CPT), Sheffield, UK.; Centre for Applied Pharmacokinetic Research (CAPKR), The University of Manchester, Manchester, UK.
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