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Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3.

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Title: Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3.
Authors: Darwesh AM; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1., Fang L; Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7., Altamimi TR; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Jamieson KL; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1., Bassiouni W; Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7., Valencia R; Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7., Huang A; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1., Wang F; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Zhang H; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada., Ahmed M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.; Quantitative Solutions, API, Edmonton, AB, Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1., Zhang Y; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada., Michelakis ED; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1., Edin ML; National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC, USA., Zeldin DC; National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC, USA., Barakat K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, Canada., Oudit GY; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada., Kassiri Z; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Lopaschuk GD; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Seubert JM; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.; Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7.
Source: Cardiovascular research [Cardiovasc Res] 2025 Apr 22; Vol. 121 (2), pp. 267-282.
Publication Type: Journal Article
Journal Info: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3.
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  Data: <searchLink fieldCode="AU" term="%22Darwesh+AM%22">Darwesh AM</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.<br /><searchLink fieldCode="AU" term="%22Fang+L%22">Fang L</searchLink>; Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7.<br /><searchLink fieldCode="AU" term="%22Altamimi+TR%22">Altamimi TR</searchLink>; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Jamieson+KL%22">Jamieson KL</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.<br /><searchLink fieldCode="AU" term="%22Bassiouni+W%22">Bassiouni W</searchLink>; Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7.<br /><searchLink fieldCode="AU" term="%22Valencia+R%22">Valencia R</searchLink>; Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7.<br /><searchLink fieldCode="AU" term="%22Huang+A%22">Huang A</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Ahmed+M%22">Ahmed M</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.; Quantitative Solutions, API, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Gopal+K%22">Gopal K</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Michelakis+ED%22">Michelakis ED</searchLink>; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Ussher+JR%22">Ussher JR</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.<br /><searchLink fieldCode="AU" term="%22Edin+ML%22">Edin ML</searchLink>; National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Zeldin+DC%22">Zeldin DC</searchLink>; National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Barakat+K%22">Barakat K</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Oudit+GY%22">Oudit GY</searchLink>; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Kassiri+Z%22">Kassiri Z</searchLink>; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Lopaschuk+GD%22">Lopaschuk GD</searchLink>; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Seubert+JM%22">Seubert JM</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, AB, Canada T6G 2H1.; Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7.
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        Value: 10.1093/cvr/cvae252
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              Text: 2025 Apr 22
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