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Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study.

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Title: Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study.
Authors: Rodriguez V; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.; North London NHS Foundation Trust, Camden Early Intervention Service London, London NW1 0AS, United Kingdom., Alameda L; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.; Department of Psychiatry, Instituto de Investigación Sanitaria de Sevilla, IBiS, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla 41013, Spain.; Service of General Psychiatry, Treatment and Early Intervention in Psychosis Program, Lausanne University Hospital (CHUV), 1003 Lausanne, Switzerland., Aas M; Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom., Gayer-Anderson C; Department of Health Service and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AB, United Kingdom., Trotta G; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom., Spinazzola E; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom., Quattrone D; Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom., Tripoli G; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.; Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, 90133 Palermo PA, Italy., Jongsma HE; Veldzicht Centre for Transcultural Psychiatry, 7707 AT Balkbrug, the Netherlands.; University Centre for Pyschiatry, University Medical Centre Groningen, 9713 GZ Groningen, the Netherlands., Stilo S; Department of Mental Health and Addiction Services, ASP Crotone, 88900 Crotone KR, Italy., La Cascia C; Department of Biomedicine, Section of Psychiatry, Neuroscience and advanced Diagnostic (BiND), University of Palermo, 90133 Palermo PA, Italy., Ferraro L; Department of Biomedicine, Section of Psychiatry, Neuroscience and advanced Diagnostic (BiND), University of Palermo, 90133 Palermo PA, Italy., La Barbera D; Department of Biomedicine, Section of Psychiatry, Neuroscience and advanced Diagnostic (BiND), University of Palermo, 90133 Palermo PA, Italy., Lasalvia A; Department of Neuroscience, Section of Psychiatry, Biomedicine and Movement, University of Verona, 37134 Verona, Italy., Tosato S; Department of Neuroscience, Section of Psychiatry, Biomedicine and Movement, University of Verona, 37134 Verona, Italy., Tarricone I; Department of Medical and Surgical Science, Bologna Transcultural Psychosomatic Team (BoTPT), Alma Mater Studiorum Università di Bologna, 40126 Bologna, Italy., Bonora E; Department of Medical and Surgical Science, Bologna Transcultural Psychosomatic Team (BoTPT), Alma Mater Studiorum Università di Bologna, 40126 Bologna, Italy., Jamain S; Neuropsychiatrie Translationnelle, INSERM, U955, Faculté de Santé, Université Paris Est, 94010 Créteil, France., Selten JP; Rivierduinen Institute for Mental Health Care, 2333 ZZ Leiden, the Netherlands.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, 6229 ER Maastricht, the Netherlands., Velthorst E; Department of Community Mental Health, GGZ Noord-Holland-Noord, 1850 BA, Heerhugowaard, the Netherlands., de Haan L; Department of Psychiatry, Early Psychosis Section, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands., Llorca PM; Université Clermont Auvergne, 63000 Clermont-Ferrand, France., Arrojo M; Department of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago, Spain., Bobes J; Department of Psychiatry-School of Medicine, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), INEUROPA, CIBERSAM, Mental Health Services of Principado de Asturias (SESPA), 33011 Oviedo, Spain., Bernardo M; Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer, Biomedical Research Networking Centre in Mental Health (CIBERSAM), 08017 Barcelona, Spain., Arango C; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, 28007 Madrid, Spain., Kirkbride J; Psylife Group, Division of Psychiatry, University College London, London W1T 7AD, United Kingdom., Jones PB; Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, United Kingdom.; CAMEO Early Intervention Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge CB1 2DP, United Kingdom., Rutten BP; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, 6229 ER Maastricht, the Netherlands., Richards A; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff CF10 3AT, United Kingdom., Sham PC; Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.; Centre for Genomic Sciences, Li KaShing Faculty of Medicine, University of Hong Kong, Hong Kong, China., O'Donovan M; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff CF10 3AT, United Kingdom., Van Os J; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, 6229 ER Maastricht, the Netherlands.; Department of Psychiatry, Brain Centre Rudolf Magnus, Utrecht University Medical Centre, 3584 CS Utrecht, the Netherlands., Morgan C; Department of Health Service and Population Research, ESRC Centre for Society and Mental Health, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AB, United Kingdom., Di Forti M; Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom., Murray RM; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom., Vassos E; Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.
Source: Schizophrenia bulletin [Schizophr Bull] 2025 Sep 08; Vol. 51 (5), pp. 1254-1265.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0236760 Publication Model: Print Cited Medium: Internet ISSN: 1745-1701 (Electronic) Linking ISSN: 05867614 NLM ISO Abbreviation: Schizophr Bull Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Rodriguez+V%22">Rodriguez V</searchLink>; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.; North London NHS Foundation Trust, Camden Early Intervention Service London, London NW1 0AS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Alameda+L%22">Alameda L</searchLink>; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.; Department of Psychiatry, Instituto de Investigación Sanitaria de Sevilla, IBiS, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla 41013, Spain.; Service of General Psychiatry, Treatment and Early Intervention in Psychosis Program, Lausanne University Hospital (CHUV), 1003 Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Aas+M%22">Aas M</searchLink>; Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gayer-Anderson+C%22">Gayer-Anderson C</searchLink>; Department of Health Service and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AB, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Trotta+G%22">Trotta G</searchLink>; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Spinazzola+E%22">Spinazzola E</searchLink>; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Quattrone+D%22">Quattrone D</searchLink>; Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tripoli+G%22">Tripoli G</searchLink>; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.; Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, 90133 Palermo PA, Italy.<br /><searchLink fieldCode="AU" term="%22Jongsma+HE%22">Jongsma HE</searchLink>; Veldzicht Centre for Transcultural Psychiatry, 7707 AT Balkbrug, the Netherlands.; University Centre for Pyschiatry, University Medical Centre Groningen, 9713 GZ Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Stilo+S%22">Stilo S</searchLink>; Department of Mental Health and Addiction Services, ASP Crotone, 88900 Crotone KR, Italy.<br /><searchLink fieldCode="AU" term="%22La+Cascia+C%22">La Cascia C</searchLink>; Department of Biomedicine, Section of Psychiatry, Neuroscience and advanced Diagnostic (BiND), University of Palermo, 90133 Palermo PA, Italy.<br /><searchLink fieldCode="AU" term="%22Ferraro+L%22">Ferraro L</searchLink>; Department of Biomedicine, Section of Psychiatry, Neuroscience and advanced Diagnostic (BiND), University of Palermo, 90133 Palermo PA, Italy.<br /><searchLink fieldCode="AU" term="%22La+Barbera+D%22">La Barbera D</searchLink>; Department of Biomedicine, Section of Psychiatry, Neuroscience and advanced Diagnostic (BiND), University of Palermo, 90133 Palermo PA, Italy.<br /><searchLink fieldCode="AU" term="%22Lasalvia+A%22">Lasalvia A</searchLink>; Department of Neuroscience, Section of Psychiatry, Biomedicine and Movement, University of Verona, 37134 Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Tosato+S%22">Tosato S</searchLink>; Department of Neuroscience, Section of Psychiatry, Biomedicine and Movement, University of Verona, 37134 Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Tarricone+I%22">Tarricone I</searchLink>; Department of Medical and Surgical Science, Bologna Transcultural Psychosomatic Team (BoTPT), Alma Mater Studiorum Università di Bologna, 40126 Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Bonora+E%22">Bonora E</searchLink>; Department of Medical and Surgical Science, Bologna Transcultural Psychosomatic Team (BoTPT), Alma Mater Studiorum Università di Bologna, 40126 Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Jamain+S%22">Jamain S</searchLink>; Neuropsychiatrie Translationnelle, INSERM, U955, Faculté de Santé, Université Paris Est, 94010 Créteil, France.<br /><searchLink fieldCode="AU" term="%22Selten+JP%22">Selten JP</searchLink>; Rivierduinen Institute for Mental Health Care, 2333 ZZ Leiden, the Netherlands.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, 6229 ER Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Velthorst+E%22">Velthorst E</searchLink>; Department of Community Mental Health, GGZ Noord-Holland-Noord, 1850 BA, Heerhugowaard, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Haan+L%22">de Haan L</searchLink>; Department of Psychiatry, Early Psychosis Section, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Llorca+PM%22">Llorca PM</searchLink>; Université Clermont Auvergne, 63000 Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Arrojo+M%22">Arrojo M</searchLink>; Department of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago, Spain.<br /><searchLink fieldCode="AU" term="%22Bobes+J%22">Bobes J</searchLink>; Department of Psychiatry-School of Medicine, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), INEUROPA, CIBERSAM, Mental Health Services of Principado de Asturias (SESPA), 33011 Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Bernardo+M%22">Bernardo M</searchLink>; Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer, Biomedical Research Networking Centre in Mental Health (CIBERSAM), 08017 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arango+C%22">Arango C</searchLink>; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, 28007 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Kirkbride+J%22">Kirkbride J</searchLink>; Psylife Group, Division of Psychiatry, University College London, London W1T 7AD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jones+PB%22">Jones PB</searchLink>; Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, United Kingdom.; CAMEO Early Intervention Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge CB1 2DP, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rutten+BP%22">Rutten BP</searchLink>; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, 6229 ER Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Richards+A%22">Richards A</searchLink>; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff CF10 3AT, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sham+PC%22">Sham PC</searchLink>; Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.; Centre for Genomic Sciences, Li KaShing Faculty of Medicine, University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22O'Donovan+M%22">O'Donovan M</searchLink>; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff CF10 3AT, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Van+Os+J%22">Van Os J</searchLink>; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, 6229 ER Maastricht, the Netherlands.; Department of Psychiatry, Brain Centre Rudolf Magnus, Utrecht University Medical Centre, 3584 CS Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Morgan+C%22">Morgan C</searchLink>; Department of Health Service and Population Research, ESRC Centre for Society and Mental Health, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AB, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Di+Forti+M%22">Di Forti M</searchLink>; Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Murray+RM%22">Murray RM</searchLink>; Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London SE5 8AB, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vassos+E%22">Vassos E</searchLink>; Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.
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