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Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma.

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Title: Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma.
Authors: Papargyriou A; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany., Najajreh M; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany., Cook DP; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Maurer CH; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany., Bärthel S; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Messal HA; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Ravichandran SK; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany., Richter T; Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.; Department of Mathematics, School of Computing, Information and Technology, Technical University of Munich, Munich, Germany., Knolle M; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.; Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany., Metzler T; Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Munich, Germany., Shastri AR; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany., Öllinger R; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany., Jasper J; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany., Schmidleitner L; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany., Wang S; Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Schneeweis C; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Ishikawa-Ankerhold H; Department of Medicine I, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany., Engleitner T; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany., Mataite L; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany., Semina M; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany., Trabulssi H; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany., Lange S; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany., Ravichandra A; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany., Schuster M; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany., Mueller S; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany., Peschke K; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany., Schäfer A; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany., Dobiasch S; Department of Radiation Oncology, Technical University of Munich, Munich, Germany.; Institute of Radiation Medicine (IRM), Helmholtz Zentrum München, Neuherberg, Germany., Combs SE; Department of Radiation Oncology, Technical University of Munich, Munich, Germany.; Institute of Radiation Medicine (IRM), Helmholtz Zentrum München, Neuherberg, Germany., Schmid RM; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany., Bausch AR; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.; Lehrstuhl für Zell Biophysik E27, Physik Department, Technische Universität München, Garching, Germany., Braren R; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany., Heid I; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany., Scheel CH; Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.; Department of Dermatology, Ruhr-University Bochum, Bochum, Germany., Schneider G; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Zeigerer A; Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Luecken MD; Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), München, Germany., Steiger K; Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Munich, Germany., Kaissis G; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.; Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.; Institute for Machine Learning in Biomedical Imaging, Helmholtz Zentrum München, München, Germany.; Department of Computing, Imperial College London, London, UK.; Munich Center for Machine Learning (MCML), München, Germany.; School of Computation, Information and Technology, Technische Universität München, München, Germany., van Rheenen J; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Theis FJ; Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.; Department of Mathematics, School of Computing, Information and Technology, Technical University of Munich, Munich, Germany.; Cellular Genetics Programme, Wellcome Sanger Institute, Hinxton, Cambridge, UK., Saur D; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Rad R; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany., Reichert M; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany. maximilian.reichert@tum.de.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany. maximilian.reichert@tum.de.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany. maximilian.reichert@tum.de.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany. maximilian.reichert@tum.de.; Bavarian Cancer Research Center (BZKF), Munich, Germany. maximilian.reichert@tum.de.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany. maximilian.reichert@tum.de.; Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Munich, Germany. maximilian.reichert@tum.de.
Source: Nature biomedical engineering [Nat Biomed Eng] 2025 Jun; Vol. 9 (6), pp. 836-864. Date of Electronic Publication: 2024 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Papargyriou+A%22">Papargyriou A</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Najajreh+M%22">Najajreh M</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Cook+DP%22">Cook DP</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Maurer+CH%22">Maurer CH</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.<br /><searchLink fieldCode="AU" term="%22Bärthel+S%22">Bärthel S</searchLink>; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Messal+HA%22">Messal HA</searchLink>; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ravichandran+SK%22">Ravichandran SK</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+T%22">Richter T</searchLink>; Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.; Department of Mathematics, School of Computing, Information and Technology, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Knolle+M%22">Knolle M</searchLink>; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.; Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Metzler+T%22">Metzler T</searchLink>; Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Shastri+AR%22">Shastri AR</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Öllinger+R%22">Öllinger R</searchLink>; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jasper+J%22">Jasper J</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidleitner+L%22">Schmidleitner L</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schneeweis+C%22">Schneeweis C</searchLink>; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ishikawa-Ankerhold+H%22">Ishikawa-Ankerhold H</searchLink>; Department of Medicine I, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Engleitner+T%22">Engleitner T</searchLink>; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mataite+L%22">Mataite L</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Semina+M%22">Semina M</searchLink>; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Trabulssi+H%22">Trabulssi H</searchLink>; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lange+S%22">Lange S</searchLink>; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ravichandra+A%22">Ravichandra A</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schuster+M%22">Schuster M</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Mueller+S%22">Mueller S</searchLink>; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Peschke+K%22">Peschke K</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Schäfer+A%22">Schäfer A</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Dobiasch+S%22">Dobiasch S</searchLink>; Department of Radiation Oncology, Technical University of Munich, Munich, Germany.; Institute of Radiation Medicine (IRM), Helmholtz Zentrum München, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Combs+SE%22">Combs SE</searchLink>; Department of Radiation Oncology, Technical University of Munich, Munich, Germany.; Institute of Radiation Medicine (IRM), Helmholtz Zentrum München, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+RM%22">Schmid RM</searchLink>; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bausch+AR%22">Bausch AR</searchLink>; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.; Lehrstuhl für Zell Biophysik E27, Physik Department, Technische Universität München, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Braren+R%22">Braren R</searchLink>; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Heid+I%22">Heid I</searchLink>; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Scheel+CH%22">Scheel CH</searchLink>; Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.; Department of Dermatology, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+G%22">Schneider G</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Zeigerer+A%22">Zeigerer A</searchLink>; Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Luecken+MD%22">Luecken MD</searchLink>; Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), München, Germany.<br /><searchLink fieldCode="AU" term="%22Steiger+K%22">Steiger K</searchLink>; Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kaissis+G%22">Kaissis G</searchLink>; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.; Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.; Institute for Machine Learning in Biomedical Imaging, Helmholtz Zentrum München, München, Germany.; Department of Computing, Imperial College London, London, UK.; Munich Center for Machine Learning (MCML), München, Germany.; School of Computation, Information and Technology, Technische Universität München, München, Germany.<br /><searchLink fieldCode="AU" term="%22van+Rheenen+J%22">van Rheenen J</searchLink>; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Theis+FJ%22">Theis FJ</searchLink>; Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.; Department of Mathematics, School of Computing, Information and Technology, Technical University of Munich, Munich, Germany.; Cellular Genetics Programme, Wellcome Sanger Institute, Hinxton, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Saur+D%22">Saur D</searchLink>; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rad+R%22">Rad R</searchLink>; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Reichert+M%22">Reichert M</searchLink>; Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany. maximilian.reichert@tum.de.; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany. maximilian.reichert@tum.de.; Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany. maximilian.reichert@tum.de.; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany. maximilian.reichert@tum.de.; Bavarian Cancer Research Center (BZKF), Munich, Germany. maximilian.reichert@tum.de.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany. maximilian.reichert@tum.de.; Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Munich, Germany. maximilian.reichert@tum.de.
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  Data: <searchLink fieldCode="JN" term="%22101696896%22">Nature biomedical engineering</searchLink> [Nat Biomed Eng] 2025 Jun; Vol. 9 (6), pp. 836-864. <i>Date of Electronic Publication: </i>2024 Dec 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101696896 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2157-846X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222157846X%22">2157846X </searchLink><i>NLM ISO Abbreviation: </i>Nat Biomed Eng <i>Subsets: </i>MEDLINE
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