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Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial.

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Title: Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial.
Authors: Meattini I; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. Electronic address: icro.meattini@unifi.it., De Santis MC; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy., Visani L; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy., Scorsetti M; Department of Radiotherapy and Radiosurgery, Istituto Clinico Humanitas - Humanitas Cancer Center, Milan, Italy., Fozza A; Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Meduri B; Department of Radiation Oncology, University Hospital of Modena, Modena, Italy., De Rose F; Department of Radiation Oncology, Santa Chiara Hospital, Trento, Italy., Bonzano E; Department of Radiation Oncology, IRCCS San Matteo Polyclinic Foundation, Pavia, Italy., Prisco A; Department of Radiation Oncology, 'Santa Maria della Misericordia' University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy., Masiello V; UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy., La Rocca E; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy., Spoto R; Department of Radiotherapy and Radiosurgery, Istituto Clinico Humanitas - Humanitas Cancer Center, Milan, Italy., Becherini C; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy., Blandino G; Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Moscetti L; Oncology and Hematology Department, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy., Colciago RR; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy., Audisio RA; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital, Göteborg, Sweden., Brain E; Paris Sciences and Lettres University, Paris, France; Institut Curie, Hopital René Huguenin, Saint-Cloud, France., Caini S; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy., Hamaker M; Department of Geriatric Medicine, Diakonessenhuis Utrecht, Utrecht, Netherlands., Kaidar-Person O; Breast Cancer Radiation Therapy Unit, Sheba Medical Center, Ramat Gan, Israel; The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; GROW-School for Oncology and Reproduction (Maastro), Maastricht University, Maastricht, Netherlands., Lambertini M; Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genova, Italy; Department of Medical Oncology, UOC Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Marrazzo L; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Medical Physics Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy., Saieva C; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy., Spanic T; Europa Donna, European Breast Cancer Coalition, Milan, Italy; Europa Donna Slovenia, Ljubljana, Slovenia., Strnad V; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Wheelwright S; Sussex Health Outcomes Research & Education in Cancer (SHORE-C), Brighton & Sussex Medical School, University of Sussex, Brighton, East Sussex, UK., Poortmans PMP; Department of Radiation Oncology, Iridium Netwerk, Wilrijk-Antwerp, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk-Antwerp, Belgium., Livi L; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
Corporate Authors: EUROPA Trial Investigators
Source: The Lancet. Oncology [Lancet Oncol] 2025 Jan; Vol. 26 (1), pp. 37-50. Date of Electronic Publication: 2024 Dec 12.
Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study; Comparative Study; Equivalence Trial
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial.
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  Data: <searchLink fieldCode="AU" term="%22Meattini+I%22">Meattini I</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. Electronic address: icro.meattini@unifi.it.<br /><searchLink fieldCode="AU" term="%22De+Santis+MC%22">De Santis MC</searchLink>; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Visani+L%22">Visani L</searchLink>; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Scorsetti+M%22">Scorsetti M</searchLink>; Department of Radiotherapy and Radiosurgery, Istituto Clinico Humanitas - Humanitas Cancer Center, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fozza+A%22">Fozza A</searchLink>; Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Meduri+B%22">Meduri B</searchLink>; Department of Radiation Oncology, University Hospital of Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22De+Rose+F%22">De Rose F</searchLink>; Department of Radiation Oncology, Santa Chiara Hospital, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Bonzano+E%22">Bonzano E</searchLink>; Department of Radiation Oncology, IRCCS San Matteo Polyclinic Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Prisco+A%22">Prisco A</searchLink>; Department of Radiation Oncology, 'Santa Maria della Misericordia' University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Masiello+V%22">Masiello V</searchLink>; UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22La+Rocca+E%22">La Rocca E</searchLink>; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Spoto+R%22">Spoto R</searchLink>; Department of Radiotherapy and Radiosurgery, Istituto Clinico Humanitas - Humanitas Cancer Center, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Becherini+C%22">Becherini C</searchLink>; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Blandino+G%22">Blandino G</searchLink>; Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Moscetti+L%22">Moscetti L</searchLink>; Oncology and Hematology Department, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Colciago+RR%22">Colciago RR</searchLink>; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Audisio+RA%22">Audisio RA</searchLink>; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital, Göteborg, Sweden.<br /><searchLink fieldCode="AU" term="%22Brain+E%22">Brain E</searchLink>; Paris Sciences and Lettres University, Paris, France; Institut Curie, Hopital René Huguenin, Saint-Cloud, France.<br /><searchLink fieldCode="AU" term="%22Caini+S%22">Caini S</searchLink>; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Hamaker+M%22">Hamaker M</searchLink>; Department of Geriatric Medicine, Diakonessenhuis Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kaidar-Person+O%22">Kaidar-Person O</searchLink>; Breast Cancer Radiation Therapy Unit, Sheba Medical Center, Ramat Gan, Israel; The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; GROW-School for Oncology and Reproduction (Maastro), Maastricht University, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Lambertini+M%22">Lambertini M</searchLink>; Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genova, Italy; Department of Medical Oncology, UOC Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Marrazzo+L%22">Marrazzo L</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Medical Physics Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Saieva+C%22">Saieva C</searchLink>; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Spanic+T%22">Spanic T</searchLink>; Europa Donna, European Breast Cancer Coalition, Milan, Italy; Europa Donna Slovenia, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Strnad+V%22">Strnad V</searchLink>; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Wheelwright+S%22">Wheelwright S</searchLink>; Sussex Health Outcomes Research & Education in Cancer (SHORE-C), Brighton & Sussex Medical School, University of Sussex, Brighton, East Sussex, UK.<br /><searchLink fieldCode="AU" term="%22Poortmans+PMP%22">Poortmans PMP</searchLink>; Department of Radiation Oncology, Iridium Netwerk, Wilrijk-Antwerp, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk-Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Livi+L%22">Livi L</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
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