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Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress.

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Title: Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress.
Authors: Mahmoud NM; Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Elshazly SM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt., El-Shaarawy F; Department of Biochemistry, Faculty of Pharmacy, Sinai University, Arish, Egypt., Zaitone SA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia., Aldahish AA; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Ahmed GA; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Fawzy MS; Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.; Center for Health Research, Northern Border University, Arar, Saudi Arabia., Aloyouni SY; Research Department, Natural and Health Sciences Research Center, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Abed SY; Department of Respiratory Care, College of Applied Medical Science in Jubail, Imam Abdulrahman Bin Faisal University, Jubail, Saudi Arabia., Saeedi T; Department of Pharmacology and Toxicology, School of Pharmacy, Taibah University, Medina, Saudi Arabia., El-Sayed SS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Source: Frontiers in pharmacology [Front Pharmacol] 2024 Dec 02; Vol. 15, pp. 1491249. Date of Electronic Publication: 2024 Dec 02 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress.
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  Data: <searchLink fieldCode="AU" term="%22Mahmoud+NM%22">Mahmoud NM</searchLink>; Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Elshazly+SM%22">Elshazly SM</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Shaarawy+F%22">El-Shaarawy F</searchLink>; Department of Biochemistry, Faculty of Pharmacy, Sinai University, Arish, Egypt.<br /><searchLink fieldCode="AU" term="%22Zaitone+SA%22">Zaitone SA</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aldahish+AA%22">Aldahish AA</searchLink>; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ahmed+GA%22">Ahmed GA</searchLink>; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Fawzy+MS%22">Fawzy MS</searchLink>; Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.; Center for Health Research, Northern Border University, Arar, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aloyouni+SY%22">Aloyouni SY</searchLink>; Research Department, Natural and Health Sciences Research Center, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abed+SY%22">Abed SY</searchLink>; Department of Respiratory Care, College of Applied Medical Science in Jubail, Imam Abdulrahman Bin Faisal University, Jubail, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Saeedi+T%22">Saeedi T</searchLink>; Department of Pharmacology and Toxicology, School of Pharmacy, Taibah University, Medina, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22El-Sayed+SS%22">El-Sayed SS</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2024 Dec 02; Vol. 15, pp. 1491249. <i>Date of Electronic Publication: </i>2024 Dec 02 (<i>Print Publication: </i>2024).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media]%22">Frontiers Media] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101548923 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-9812 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216639812%22">16639812 </searchLink><i>NLM ISO Abbreviation: </i>Front Pharmacol <i>Subsets: </i>PubMed not MEDLINE
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