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Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States.

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Title: Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States.
Authors: George SL; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.; Children and Young People's Unit, The Royal Marsden Hospital, London, United Kingdom., Lynn C; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Stankunaite R; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Hughes D; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Sauer CM; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Chalker J; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Waqar Ahmed S; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Oostveen M; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Proszek PZ; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Yuan L; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Shaikh R; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Jamal S; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Brew A; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Tall J; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom., Rogers T; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom., Clifford SC; Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom., Vormoor J; Princess Máxima Center and University Medical Center, Utrecht, the Netherlands., Shipley JM; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Tweddle DA; Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom., Jones C; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Willis C; Royal Aberdeen Children's Hospital, Aberdeen, United Kingdom., Burke GAA; Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Vedi A; Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom., Howell L; Alder-Hey Children's Hospital, Liverpool, United Kingdom., Johnston R; Royal Belfast Hospital for Sick Children, Belfast, United Kingdom., Rees H; Bristol Royal Hospital for Children, Bristol, United Kingdom., Adams M; Noah's Ark Children's Hospital for Wales, Cardiff, United Kingdom., Jesudason A; Royal Hospital for Sick Children, Edinburgh, United Kingdom., Ronghe M; Royal Hospital for Children, Glasgow, United Kingdom., Elliott M; Leeds General Infirmary, Leeds, United Kingdom., Ross E; Leicester Royal Infirmary, Leicester, United Kingdom., Makin G; Royal Manchester Children's Hospital, Manchester, United Kingdom., Campbell-Hewson Q; Great North Children's Hospital, Newcastle upon Tyne, United Kingdom., Grundy RG; Queen's Medical Centre, Nottingham, United Kingdom., Turnbull J; Queen's Medical Centre, Nottingham, United Kingdom., Wilson S; John Radcliffe Hospital, Oxford, United Kingdom., Lee V; Sheffield Children's Hospital, Sheffield, United Kingdom., Gray JC; Southampton General Hospital, Southampton, United Kingdom., Stoneham S; University College London, London, United Kingdom., Gatz SA; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.; Birmingham Children's Hospital, Birmingham, United Kingdom., Marshall LV; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.; Children and Young People's Unit, The Royal Marsden Hospital, London, United Kingdom., Angelini P; Children and Young People's Unit, The Royal Marsden Hospital, London, United Kingdom.; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Anderson J; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.; Developmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, United Kingdom., Cresswell GD; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.; St. Anna Children's Cancer Research Institute, Vienna, Austria., Graham TA; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Al-Lazikani B; Department of Genomic Medicine and the Therapeutics Discovery Division, MD Anderson Cancer Center, Houston, Texas., Cortés-Ciriano I; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Kearns P; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Hutchinson JC; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Hargrave D; Developmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, United Kingdom.; Haematology and Oncology Department, Great Ormond Street Hospital, London, United Kingdom., Jacques TS; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.; Developmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, United Kingdom., Hubank M; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Sottoriva A; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Chesler L; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.; Children and Young People's Unit, The Royal Marsden Hospital, London, United Kingdom.
Source: Cancer discovery [Cancer Discov] 2025 Apr 02; Vol. 15 (4), pp. 717-732.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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