Absorption, single-dose and steady-state metabolism, excretion, and pharmacokinetics of adagrasib, a KRASG12C inhibitor.
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| Title: | Absorption, single-dose and steady-state metabolism, excretion, and pharmacokinetics of adagrasib, a KRASG12C inhibitor. |
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| Authors: | Rahbaek L; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA. Lisa.rahbaek@gmail.com., Cilliers C; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA., Wegerski CJ; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA.; DMPK, Atomwise Inc,, San Francisco, CA, USA., Nguyen N; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA., Otten J; Array Biopharma Inc., Boulder, CA, USA.; ADME/DMPK, Loxo@Lilly Inc., Boulder, CA, USA., Hargis L; Mirati Therapeutics Inc., San Diego, CA, USA.; Department of Chemistry, The Scripps Research Institute, San Diego, CA, USA., Marx MA; Drug Discovery, Mirati Therapeutics Inc., San Diego, CA, USA., Christensen JG; Mirati Therapeutics Inc., San Diego, CA, USA., Tran JQ; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA. |
| Source: | Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2024 Dec 19; Vol. 95 (1), pp. 7. Date of Electronic Publication: 2024 Dec 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-0843 |
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| DOI: | 10.1007/s00280-024-04728-7 |
