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Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells.

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Title: Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells.
Authors: Zhang Z; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Langenbach M; Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Sagar S; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Fetsch V; Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Stritzker J; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Severa E; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Meng K; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Winkler F; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Rana N; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Zoldan K; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Godbole I; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Solis S; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Weber JS; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Rafei-Shamsabadi D; Department of Dermatology and Venereology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Lehr S; Department of Dermatology and Venereology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Diehl R; Department of Dermatology and Venereology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Venhoff AC; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Voll RE; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Buettner N; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Neumann-Haefelin C; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.; Department of Gastroenterology and Hepatology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany., Boettler T; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Hofmann M; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, University Medical Center Freiburg, Freiburg, Germany., Meiss F; Department of Dermatology and Venereology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Zeiser R; Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Thimme R; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany., Herati RS; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Bengsch B; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de.; German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de.
Source: Nature immunology [Nat Immunol] 2025 Jan; Vol. 26 (1), pp. 92-104. Date of Electronic Publication: 2024 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1<superscript>+</superscript>CD8<superscript>+</superscript> T cells.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Langenbach+M%22">Langenbach M</searchLink>; Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sagar+S%22">Sagar S</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fetsch+V%22">Fetsch V</searchLink>; Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Stritzker+J%22">Stritzker J</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Severa+E%22">Severa E</searchLink>; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Meng+K%22">Meng K</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Winkler+F%22">Winkler F</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rana+N%22">Rana N</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zoldan+K%22">Zoldan K</searchLink>; 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Department of Dermatology and Venereology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Diehl+R%22">Diehl R</searchLink>; Department of Dermatology and Venereology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Venhoff+AC%22">Venhoff AC</searchLink>; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Voll+RE%22">Voll RE</searchLink>; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Buettner+N%22">Buettner N</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Neumann-Haefelin+C%22">Neumann-Haefelin C</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.; Department of Gastroenterology and Hepatology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Boettler+T%22">Boettler T</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hofmann+M%22">Hofmann M</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Boerries+M%22">Boerries M</searchLink>; Institute of Medical Bioinformatics and Systems Medicine, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Meiss+F%22">Meiss F</searchLink>; Department of Dermatology and Venereology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zeiser+R%22">Zeiser R</searchLink>; Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Thimme+R%22">Thimme R</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Herati+RS%22">Herati RS</searchLink>; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bengsch+B%22">Bengsch B</searchLink>; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de.; German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de.
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