Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells. - Zhang Z; Langenbach M; Sagar S; Fetsch V; Stritzker J; Severa E; Meng K; Winkler F; Rana N; Zoldan K; Godbole I; Solis S; et al. (Nature immunology, 2025)