Safety and immunogenicity of an acellular pertussis vaccine containing genetically detoxified pertussis toxin administered to pregnant women living with and without HIV and their newborns (WoMANPOWER): a randomised controlled trial in Uganda.

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Title: Safety and immunogenicity of an acellular pertussis vaccine containing genetically detoxified pertussis toxin administered to pregnant women living with and without HIV and their newborns (WoMANPOWER): a randomised controlled trial in Uganda.
Authors: Nakabembe E; Department of Obstetrics and Gynaecology, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; Centre for Neonatal and Paediatric Infection and Vaccine Institute, City St George's, University of London, London, UK. Electronic address: drevena@yahoo.co.uk., Greenland M; Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, Department of Paediatrics, University of Oxford, Oxford, UK., Amaral K; Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada; Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada., Abu-Raya B; Departments of Paediatrics, Dalhousie University, Halifax, NS, Canada., Amone A; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda., Andrews N; UK Health Security Agency, Immunisation and Vaccine Preventable Diseases Department, London, UK., Cantrell L; Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, Department of Paediatrics, University of Oxford, Oxford, UK., Lesne E; UK Health Security Agency, Salisbury, UK., Gorringe A; UK Health Security Agency, Salisbury, UK., Halkerston R; UK Health Security Agency, Salisbury, UK., Mcstraw N; UK Health Security Agency, Salisbury, UK., Dixon L; UK Health Security Agency, Salisbury, UK., Hunter OF; Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada., Heath PT; Centre for Neonatal and Paediatric Infection and Vaccine Institute, City St George's, University of London, London, UK., Imede E; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda., Kyohere M; Centre for Neonatal and Paediatric Infection and Vaccine Institute, City St George's, University of London, London, UK; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda., Musoke P; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda., Nakimuli A; Department of Obstetrics and Gynaecology, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Sekikubo M; Department of Obstetrics and Gynaecology, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Taylor S; UK Health Security Agency, Salisbury, UK., Tusubira V; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda., Sadarangani M; Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada; Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada., Le Doare K; Centre for Neonatal and Paediatric Infection and Vaccine Institute, City St George's, University of London, London, UK; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda; UK Health Security Agency, Salisbury, UK.
Source: The Lancet. Global health [Lancet Glob Health] 2025 Jan; Vol. 13 (1), pp. e81-e97.
Publication Type: Clinical Trial, Phase II; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101613665 Publication Model: Print Cited Medium: Internet ISSN: 2214-109X (Electronic) Linking ISSN: 2214109X NLM ISO Abbreviation: Lancet Glob Health Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and immunogenicity of an acellular pertussis vaccine containing genetically detoxified pertussis toxin administered to pregnant women living with and without HIV and their newborns (WoMANPOWER): a randomised controlled trial in Uganda.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Nakabembe+E%22">Nakabembe E</searchLink>; Department of Obstetrics and Gynaecology, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; Centre for Neonatal and Paediatric Infection and Vaccine Institute, City St George's, University of London, London, UK. Electronic address: drevena@yahoo.co.uk.<br /><searchLink fieldCode="AU" term="%22Greenland+M%22">Greenland M</searchLink>; Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Amaral+K%22">Amaral K</searchLink>; Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada; Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Abu-Raya+B%22">Abu-Raya B</searchLink>; Departments of Paediatrics, Dalhousie University, Halifax, NS, Canada.<br /><searchLink fieldCode="AU" term="%22Amone+A%22">Amone A</searchLink>; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Andrews+N%22">Andrews N</searchLink>; UK Health Security Agency, Immunisation and Vaccine Preventable Diseases Department, London, UK.<br /><searchLink fieldCode="AU" term="%22Cantrell+L%22">Cantrell L</searchLink>; Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lesne+E%22">Lesne E</searchLink>; UK Health Security Agency, Salisbury, UK.<br /><searchLink fieldCode="AU" term="%22Gorringe+A%22">Gorringe A</searchLink>; UK Health Security Agency, Salisbury, UK.<br /><searchLink fieldCode="AU" term="%22Halkerston+R%22">Halkerston R</searchLink>; UK Health Security Agency, Salisbury, UK.<br /><searchLink fieldCode="AU" term="%22Mcstraw+N%22">Mcstraw N</searchLink>; UK Health Security Agency, Salisbury, UK.<br /><searchLink fieldCode="AU" term="%22Dixon+L%22">Dixon L</searchLink>; UK Health Security Agency, Salisbury, UK.<br /><searchLink fieldCode="AU" term="%22Hunter+OF%22">Hunter OF</searchLink>; Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Heath+PT%22">Heath PT</searchLink>; Centre for Neonatal and Paediatric Infection and Vaccine Institute, City St George's, University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Imede+E%22">Imede E</searchLink>; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.<br /><searchLink fieldCode="AU" term="%22Kyohere+M%22">Kyohere M</searchLink>; Centre for Neonatal and Paediatric Infection and Vaccine Institute, City St George's, University of London, London, UK; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Musoke+P%22">Musoke P</searchLink>; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Nakimuli+A%22">Nakimuli A</searchLink>; Department of Obstetrics and Gynaecology, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Sekikubo+M%22">Sekikubo M</searchLink>; Department of Obstetrics and Gynaecology, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Taylor+S%22">Taylor S</searchLink>; UK Health Security Agency, Salisbury, UK.<br /><searchLink fieldCode="AU" term="%22Tusubira+V%22">Tusubira V</searchLink>; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Sadarangani+M%22">Sadarangani M</searchLink>; Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada; Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Le+Doare+K%22">Le Doare K</searchLink>; Centre for Neonatal and Paediatric Infection and Vaccine Institute, City St George's, University of London, London, UK; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda; UK Health Security Agency, Salisbury, UK.
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  Data: <searchLink fieldCode="JN" term="%22101613665%22">The Lancet. Global health</searchLink> [Lancet Glob Health] 2025 Jan; Vol. 13 (1), pp. e81-e97.
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  Data: Clinical Trial, Phase II; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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