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Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum.

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Title: Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum.
Authors: Trelle AN; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Young CB; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Vossler H; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Ramos Benitez J; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Cody KA; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Mendiola JH; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Swarovski MS; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Guen YL; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Quantitative Sciences Unit, Department of Medicine, Stanford University, Palo Alto, California, USA., Feinstein I; Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California, USA., Butler RR 3rd; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Channappa D; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Romero A; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Park J; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Shahid-Besanti M; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Corso NK; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Chau K; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Smith AN; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Skylar-Scott I; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Yutsis MV; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Fredericks CA; Neurology, Yale University, New Haven, Connecticut, USA., Tian L; Biomedical Data Science and Statistics, Stanford University, Stanford, California, USA., Younes K; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Kerchner GA; Pharma Research and Early Development, F. Hoffmann-La Roche, Ltd., Basel, Switzerland., Deutsch GK; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Davidzon GA; Radiology, Stanford University, Stanford, California, USA., Sha SJ; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Henderson VW; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Department of Epidemiology & Population Health, Stanford University, Stanford, California, USA., Longo FM; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Greicius MD; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Wyss-Coray T; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Andreasson KI; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Poston KL; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.; Neurosurgery, Stanford University, Stanford, California, USA., Wagner AD; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Psychology, Stanford University, Stanford, California, USA., Mormino EC; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Wilson EN; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Feb; Vol. 21 (2), pp. e14442. Date of Electronic Publication: 2024 Dec 23.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Plasma Aβ<subscript>42</subscript>/Aβ<subscript>40</subscript> is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum.
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