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Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype.

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Title: Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype.
Authors: Shvetcov A; Translational Dementia Research Group, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.; Department of Psychological Medicine, Sydney Children's Hospital Network, Sydney, NSW, Australia.; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Thomson S; Translational Dementia Research Group, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Cho AN; Human Brain Microphysiology Systems Group, School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Sydney, NSW, Australia., Wilkins HM; University of Kansas Alzheimer's Disease Research Centre, Kansas City, KS, USA.; Department of Biochemistry and Molecular Biology, University of Kansas Medical Centre, Kansas City, KS, USA.; Department of Neurology, University of Kansas Medical Centre, Kansas City, KS, USA., Reed JH; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Autoimmunity and Amyloidosis Research Group, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia., Swerdlow RH; University of Kansas Alzheimer's Disease Research Centre, Kansas City, KS, USA.; Department of Biochemistry and Molecular Biology, University of Kansas Medical Centre, Kansas City, KS, USA.; Department of Neurology, University of Kansas Medical Centre, Kansas City, KS, USA.; Department of Molecular and Integrative Physiology, University of Kansas Medical Centre, Kansas City, KS, USA., Brown DA; Neuroinflammation Research Group, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.; Department of Immunopathology, Institute for Clinical Pathology and Medical Research-New South Wales Health Pathology, Sydney, NSW, Australia.; Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Finney CA; Translational Dementia Research Group, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Corporate Authors: Alzheimer's Disease Neuroimaging Initiative
Source: Aging cell [Aging Cell] 2025 Apr; Vol. 24 (4), pp. e14439. Date of Electronic Publication: 2024 Dec 25.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype.
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  Data: <searchLink fieldCode="AU" term="%22Shvetcov+A%22">Shvetcov A</searchLink>; Translational Dementia Research Group, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.; Department of Psychological Medicine, Sydney Children's Hospital Network, Sydney, NSW, Australia.; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Thomson+S%22">Thomson S</searchLink>; Translational Dementia Research Group, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cho+AN%22">Cho AN</searchLink>; Human Brain Microphysiology Systems Group, School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wilkins+HM%22">Wilkins HM</searchLink>; University of Kansas Alzheimer's Disease Research Centre, Kansas City, KS, USA.; Department of Biochemistry and Molecular Biology, University of Kansas Medical Centre, Kansas City, KS, USA.; Department of Neurology, University of Kansas Medical Centre, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Reed+JH%22">Reed JH</searchLink>; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Autoimmunity and Amyloidosis Research Group, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Swerdlow+RH%22">Swerdlow RH</searchLink>; University of Kansas Alzheimer's Disease Research Centre, Kansas City, KS, USA.; Department of Biochemistry and Molecular Biology, University of Kansas Medical Centre, Kansas City, KS, USA.; Department of Neurology, University of Kansas Medical Centre, Kansas City, KS, USA.; Department of Molecular and Integrative Physiology, University of Kansas Medical Centre, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Brown+DA%22">Brown DA</searchLink>; Neuroinflammation Research Group, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.; Department of Immunopathology, Institute for Clinical Pathology and Medical Research-New South Wales Health Pathology, Sydney, NSW, Australia.; Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Finney+CA%22">Finney CA</searchLink>; Translational Dementia Research Group, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
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  Data: <searchLink fieldCode="JN" term="%22101130839%22">Aging cell</searchLink> [Aging Cell] 2025 Apr; Vol. 24 (4), pp. e14439. <i>Date of Electronic Publication: </i>2024 Dec 25.
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              Text: 2025 Apr
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