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Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction.

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Title: Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction.
Authors: Zhao X; Department of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Langone Health, New York, New York., Liu B; Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., William WN; Grupo Oncoclínicas, São Paulo, Brazil; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Moores Cancer Center, University of California, San Diego, La Jolla, California; Department of Medicine, University of California, San Diego, La Jolla, California., Tsanov KM; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York; Section of Hematology/Oncology, Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, Illinois., Ho YJ; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York., Barriga FM; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York., Lim RJ; Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Trifas M; Department of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Langone Health, New York, New York., Khandekar A; Cellular and Molecular Medicine and Department of Bioengineering, University of California, San Diego, La Jolla, California., Du Y; Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, People's Republic of China., Lowe SW; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York; Howard Hughes Medical Institute, Chevy Chase, Maryland., Dubinett SM; Departments of Medicine, Pathology and Laboratory Medicine, and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California., Davoli T; Department of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Langone Health, New York, New York., Lippman SM; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Moores Cancer Center, University of California, San Diego, La Jolla, California; Department of Medicine, University of California, San Diego, La Jolla, California. Electronic address: slippman@health.ucsd.edu.
Source: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2025 Sep; Vol. 20 (9), pp. 1177-1236. Date of Electronic Publication: 2024 Dec 24.
Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101274235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-1380 (Electronic) Linking ISSN: 15560864 NLM ISO Abbreviation: J Thorac Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction.
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  Data: <searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Liu+B%22">Liu B</searchLink>; Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22William+WN%22">William WN</searchLink>; Grupo Oncoclínicas, São Paulo, Brazil; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Moores Cancer Center, University of California, San Diego, La Jolla, California; Department of Medicine, University of California, San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Tsanov+KM%22">Tsanov KM</searchLink>; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York; Section of Hematology/Oncology, Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Ho+YJ%22">Ho YJ</searchLink>; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Barriga+FM%22">Barriga FM</searchLink>; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Lim+RJ%22">Lim RJ</searchLink>; Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Trifas+M%22">Trifas M</searchLink>; Department of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Khandekar+A%22">Khandekar A</searchLink>; Cellular and Molecular Medicine and Department of Bioengineering, University of California, San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Du+Y%22">Du Y</searchLink>; Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Lowe+SW%22">Lowe SW</searchLink>; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York; Howard Hughes Medical Institute, Chevy Chase, Maryland.<br /><searchLink fieldCode="AU" term="%22Dubinett+SM%22">Dubinett SM</searchLink>; Departments of Medicine, Pathology and Laboratory Medicine, and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Davoli+T%22">Davoli T</searchLink>; Department of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Lippman+SM%22">Lippman SM</searchLink>; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Moores Cancer Center, University of California, San Diego, La Jolla, California; Department of Medicine, University of California, San Diego, La Jolla, California. Electronic address: slippman@health.ucsd.edu.
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  Data: <searchLink fieldCode="JN" term="%22101274235%22">Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</searchLink> [J Thorac Oncol] 2025 Sep; Vol. 20 (9), pp. 1177-1236. <i>Date of Electronic Publication: </i>2024 Dec 24.
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